Investigational Drug Details
| Drug ID: | D255 |
| Drug Name: | Olive oil |
| Synonyms: | Olive oil |
| Type: | Biological drug |
| DrugBank ID: | DB09567 |
| DrugBank Description: | Oil extracted from olives . Consists primarily of the glycerides of the fatty acids linoleic, oleic and palmitic. Used as a source of fatty acids in total parenteral nutrition and as an additive in some cosmetic products . |
| PubChem ID: | 24753271 |
| CasNo: | 8001-25-0 |
| Repositioning for NAFLD: | Yes |
| SMILES: | O(C(=O)CCCCCCCCCCCCCCCCC)CC.O(C(=O)CCCCCCCCCCCCCCC)CC.O(C(=O)CCCCCCC/C=C\CCCCCCCC)CC.O(C(=O)CCCCCCC/C=C\C/C=C\CCCCC)CC.O(C(=O)CCCCCCC/C=C\C/C=C\C/C=C\CC)CC |
| Structure: |
|
| InChiKey: | NWUIOBPENFDKLG-IBAIYALWSA-N |
| Molecular Weight: | 1522.54 |
| DrugBank Targets: | -- |
| DrugBank MoA: | Fatty acids act as a substrate in energy production through beta-oxidation as well as important components of cell membrane structures and prescursors for bioactive molecules like prostaglandins . |
| DrugBank Pharmacology: | Provides a source of calories and fatty acids . |
| DrugBank Indication: | For use in adults as a source of calories and fatty acids in total parenteral nutrition . Sometimes used as an additive in cosmetic products. |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (IRCT2016011825957N2) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0850 | IRCT2016011825957N2 | Not applicable | Not Recruiting | No Results Available | 09/02/2016 | 22 February 2018 | Details |
| L0946 | IRCT201111022709N20 | Not applicable | Not Recruiting | No Results Available | 26/12/2011 | 22 February 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00256 | 35163881 | Molecules | The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models. | Details |
| A01785 | 34618982 | FASEB J | Omega-3 carboxylic acids and fenofibrate differentially alter plasma lipid mediators in patients with non-alcoholic fatty liver disease. | Details |
| A02708 | 34277236 | Cureus | The Significance of the Mediterranean Diet in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review. | Details |
| A03665 | 33915261 | J Nutr Biochem | Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil. | Details |
| A03815 | 33859314 | Sci Rep | Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr-/-.Leiden mice without attenuation of steatohepatitis. | Details |
| A03871 | 33838229 | J Nutr Biochem | Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease. | Details |
| A05402 | 33269500 | J Gastroenterol Hepatol | Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis. | Details |
| A05686 | 33158299 | Nutrients | Investigating Whether the Mediterranean Dietary Pattern Is Integrated in Routine Dietetic Practice for Management of Chronic Conditions: A National Survey of Dietitians. | Details |
| A06347 | 32920973 | Mol Nutr Food Res | Dietary Rapeseed Oil Supplementation Reduces Hepatic Steatosis in Obese Men-A Randomized Controlled Trial. | Details |
| A06432 | 32882583 | Biomed Pharmacother | An update on β-sitosterol: A potential herbal nutraceutical for diabetic management. | Details |
| A06437 | 32881925 | PLoS One | Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance. | Details |
| A06781 | 32748581 | J Zhejiang Univ Sci B | New observations on the effect of camellia oil on fatty liver disease in rats. | Details |
| A07622 | 32417163 | Chem Biol Interact | Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein. | Details |
| A07968 | 32295122 | Nutrients | Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation. | Details |
| A07983 | 32290535 | Nutrients | Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases. | Details |
| A08249 | 32188593 | BMJ Open Diabetes Res Care | Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism. | Details |
| A08520 | 32077594 | Liver Int | The role of nutrition in non-alcoholic fatty liver disease: Pathophysiology and management. | Details |
| A08523 | 32075238 | Nutrients | Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View. | Details |
| A08733 | 32007744 | Prostaglandins Leukot Essent Fatty Acids | Iron-induced derangement in hepatic Δ-5 and Δ-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil. | Details |
| A08734 | 32007335 | Nutr Metab Cardiovasc Dis | Addition of fish oil to atherogenic high fat diet inhibited atherogenesis while olive oil did not, in LDL receptor KO mice. | Details |