Investigational Drug Details
| Drug ID: | D274 |
| Drug Name: | Phytosterol |
| Synonyms: | Phytosterols; Plant Sterol |
| Type: | Supplement |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | 222284 |
| CasNo: | 949109-75-5 |
| Repositioning for NAFLD: | No |
| SMILES: | O[C@@H]1CC2=CC[C@H]3[C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](C(C)C)CC)C)(CC[C@@H]3[C@]2(CC1)C)C |
| Structure: |
|
| InChiKey: | KZJWDPNRJALLNS-VJSFXXLFSA-N |
| Molecular Weight: | 414.718 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Hypolipidemic drug |
| Clinical Trial Progress: | Clinical trial on-going (NCT03627819) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0513 | ChiCTR1800014419 | Other | Recruiting | No Results Available | 12/01/2018 | 15 January 2018 | Details |
| L0830 | IRCT2017011531958N1 | Phase 2 | Not Recruiting | No Results Available | 20/02/2017 | 22 February 2018 | Details |
| L0921 | NCT01875978 | Not applicable | Not recruiting | Has Results | 03/06/2013 | 19 October 2017 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01093 | 34871105 | Crit Rev Food Sci Nutr | Phytosterols as bioactive food components against nonalcoholic fatty liver disease. | Details |
| A04605 | 33566044 | Food Funct | Plant sterol ester of α-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction and oxidative stress via activating AMPK signaling. | Details |
| A04987 | 33424396 | Saudi J Biol Sci | Regulatory effect of diosgenin on lipogenic genes expression in high-fat diet-induced obesity in mice. | Details |
| A05212 | 33337101 | Compr Rev Food Sci Food Saf | Phytosterols and their derivatives: Potential health-promoting uses against lipid metabolism and associated diseases, mechanism, and safety issues. | Details |
| A06432 | 32882583 | Biomed Pharmacother | An update on β-sitosterol: A potential herbal nutraceutical for diabetic management. | Details |
| A08576 | 32054543 | Br J Nutr | Combined effect of n-3 fatty acids and phytosterol esters on alleviating hepatic steatosis in non-alcoholic fatty liver disease subjects: a double-blind placebo-controlled clinical trial. | Details |
| A08990 | 31913753 | J Med Food | Effects of Phytosterol Ester on the Fatty Acid Profiles in Rats with Nonalcoholic Fatty Liver Disease. | Details |
| A09291 | 31803887 | Food Funct | The regulatory effects of phytosterol esters (PSEs) on gut flora and faecal metabolites in rats with NAFLD. | Details |
| A09918 | 31560861 | Can J Physiol Pharmacol | β-Sitosterol mitigates the development of high-fructose diet-induced nonalcoholic fatty liver disease in growing male Sprague-Dawley rats. | Details |
| A11605 | 30822462 | Prog Lipid Res | Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?" | Details |
| A11647 | 30806308 | Curr Pharm Biotechnol | Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic-related Liver Diseases and Hepatocellular Carcinoma. | Details |
| A12337 | 30509175 | BMC Genomics | Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases. | Details |
| A12502 | 30417996 | Pak J Biol Sci | Comparative Study of Orange and its Main Bioactive Constituents as Remedy for Non-alcoholic Fatty Liver in Rats. | Details |
| A12517 | 30411763 | Food Funct | Hepatoprotective mechanism of freshwater clam extract alleviates non-alcoholic fatty liver disease: elucidated in vitro and in vivo models. | Details |
| A12747 | 30305244 | Biochim Biophys Acta Mol Cell Biol Lipids | Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet. | Details |
| A14103 | 29583004 | J Agric Food Chem | Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis. | Details |
| A15576 | 28836578 | Sci Rep | Corrigendum: Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. | Details |
| A16795 | 28169366 | Sci Rep | Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. | Details |
| A17384 | 27812789 | Obes Surg | Serum Plant Sterols Associate with Gallstone Disease Independent of Weight Loss and Non-Alcoholic Fatty Liver Disease. | Details |
| A21383 | 25356831 | PLoS One | Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans. | Details |