Investigational Drug Details
| Drug ID: | D276 |
| Drug Name: | Piperine |
| Synonyms: | Bioperine |
| Type: | Chemical drug |
| DrugBank ID: | DB12582 |
| DrugBank Description: | Bioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders. |
| PubChem ID: | 638024 |
| CasNo: | 94-62-2 |
| Repositioning for NAFLD: | No |
| SMILES: | C(=C\C=C\C(=O)N1CCCCC1)/c1cc2c(cc1)OCO2 |
| Structure: |
|
| InChiKey: | MXXWOMGUGJBKIW-YPCIICBESA-N |
| Molecular Weight: | 285.343 |
| DrugBank Targets: | Nuclear receptor subfamily 1 group I member 2 |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | NR1I2 |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 3 on-going (IRCT20180802040678N2) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0429 | IRCT20121216011763N47 | Not applicable | Not Recruiting | No Results Available | 14/05/2020 | 15 June 2020 | Details |
| L0443 | IRCT20121216011763N42 | Not applicable | Recruiting | No Results Available | 10/01/2020 | 24 February 2020 | Details |
| L0457 | IRCT20180802040678N2 | Phase 3 | Recruiting | No Results Available | 13/08/2019 | 7 October 2019 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00745 | 34981468 | Adv Exp Med Biol | Curcumin and Piperine Combination for the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind Randomized Placebo-Controlled Trial. | Details |
| A05695 | 33152943 | Biomed Pharmacother | The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling. | Details |
| A08346 | 32147075 | Complement Ther Med | Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. | Details |
| A10831 | 31168845 | J Cell Biochem | Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial. | Details |
| A10875 | 31145689 | Drug Metab Pers Ther | The effect of curcumin with piperine supplementation on pro-oxidant and antioxidant balance in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. | Details |
| A11670 | 30796508 | Eur J Nutr | Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. | Details |