Investigational Drug Details
| Drug ID: | D279 |
| Drug Name: | Plantago Psyllium |
| Synonyms: | Psyllium; Psyllium husk |
| Type: | Biological drug |
| DrugBank ID: | DB11097 |
| DrugBank Description: | Platango seeds refer to the seeds collected from various species of plantago trees. It is found in some laxatives for treating occasional constipation and restoring regularity in bowel movements. Its potential benefit in maintaining remission in ulcerative colitis has been studied . Regardless, this agent is most predominantly used as a gentle laxative agent in many parts of the world that is more commonly referred as psyllium or psyllium husk. |
| PubChem ID: | -- |
| CasNo: | 8063-16-9 |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | Psyllium seeds are comprised of dietary fibre which, when mixed with water forms a gel-like mass that works as a mild laxative . This gel-like mass subsequently moves down a patient's digestive system and makes stools softer by increasing their water contents . At the same time psyllium seed lubricates the intestine, which improves the transit of stools . Moreover, as the presence of the gel-like mass increases the stool bulk it also increases the tension and/or the stretch stimulus in the bowel wall which serves to trigger bowel movements . The dietary fibre of which psyllium husk is comprised is fermented to various degrees by bacteria in the colon, resulting in production of carbon dioxide, hydrogen, methane, water, and short chain fatty acids, which are absorbed and brought into the hepatic circulation . In humans, such fibre reaches the large bowel in a highly polymerized form that is fermented to a limited extent, resulting in increased fecal concentration and excretion of short chain fatty acids . |
| DrugBank Pharmacology: | The active ingredient psyllium husk is comprised of the episperm and collapsed adjacent layers removed from the seeds of Plantago afar L. or Plantago indica L. . Psyllium husk is abundant in alimentary fibres and mucilages, with its mucilage content in particular being higher than that of other plantago species . Specifically, psyllium husk is capable of absorbing up to 40 times its own weight in water . Psyllium husk consists of 85% water-soluble fibre - it is subsequently partly fermentable (in vitro 72% unfermentable residue) and acts by hydration in the bowel . Gastrointestinal tract motility and transit rate is capable of being modified by psyllium husk via mechanical stimulation of the gut wall as a result of the increase in intestinal bulk by water and the decrease in viscosity of the luminal contents . Taken with an adequate amount of liquid (at least 30 ml per 1 g of the agent), psyllium husk produces an increased volume of intestinal contents as a result of its highly bulking properties and therefore a stretch stimulus which triggers a defecation . Concurrently, the swollen mass of mucilage generates a lubricating layer that makes the transit of the intestinal contents easier . |
| DrugBank Indication: | Indications include the treatment of patients needing a high fibre regime, perhaps for: (a) the relief of constipation, including constipation in pregnancy and the maintenance of regularity; (b) the management of bowel function in patients with colostomy, ileostomy, hemorrhoids, anal fissure, chronic diarrhea with diverticular disease, irritable bowel syndrome, and ulcerative colitis . |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | -- |
| Latest Progress: | Under investigation |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0590 | IRCT2014101811763N17 | Not applicable | Not Recruiting | No Results Available | 04/02/2016 | 22 February 2018 | Details |
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