Investigational Drug Details
| Drug ID: | D290 |
| Drug Name: | Px-104 |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | DB15416 |
| DrugBank Description: | PX-102 is under investigation in clinical trial NCT01998672 (Multiple Ascending Oral Dose Phase I Study With Px-102). |
| PubChem ID: | 50943003 |
| CasNo: | 1268244-88-7 |
| Repositioning for NAFLD: | No |
| SMILES: | Clc1c([C@H]2[C@@H](C2)c2ccc(cc2)C(=O)O)ccc(c1)OCc1c(noc1C1CC1)c1c(Cl)cccc1Cl |
| Structure: |
|
| InChiKey: | XBUXXJUEBFDQHD-SFTDATJTSA-N |
| Molecular Weight: | 554.857 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 2 completed (NCT01999101) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0016 | NCT01999101 | Phase 2 | Completed | No Results Available | October 2013 | September 29, 2016 | Details |
| L0641 | EUCTR2013-002984-24-AT | Not applicable | Not Recruiting | No Results Available | 31/07/2013 | 16 February 2015 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A06319 | 32930860 | Wien Klin Wochenschr | Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease. | Details |
| A07297 | 32552182 | Expert Opin Investig Drugs | Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH). | Details |
| A21343 | 25388536 | Curr Top Med Chem | Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities. | Details |