Investigational Drug Details
| Drug ID: | D030 |
| Drug Name: | Bergamot |
| Synonyms: | Bergamot; Bergamot Fruit Extract; Bergamot Oil, Cold-pressed; Bergamot Oil, Coldpressed; Bergamot Orange Oil; Bergamot,imitation; Citri Bergamia Aetheroleum; Citrus Aurantium Bergamia (Bergamot) Fruit Extract; Citrus Aurantium Bergamia (Bergamot) Fruit Oil; Citrus Aurantium Bergamia (Bergamot) Fruit Water; Citrus Aurantium Bergamia (Bergamot) Peel Oil; Citrus Aurantium Subsp. Bergamia Fruit Rind Oil; Citrus Aurantium Subsp. Bergamia Oil; Citrus Bergamia (Bergamot) Peel Oil; Citrus Bergamia Extract; Citrus Bergamia Fruit Rind Oil; Citrus Bergamia Oil; Citrus Bergamia Risso & Poiteau.; Citrus X Aurantium Subsp. Bergamia Fruit Rind Oil; Oil Bergamot; Oil of Bergamot |
| Type: | Biological drug |
| DrugBank ID: | DB14335 |
| DrugBank Description: | Bergamot oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. |
| PubChem ID: | 8294 |
| CasNo: | 115-95-7 |
| Repositioning for NAFLD: | No |
| SMILES: | C(CCC=C(C)C)(OC(=O)C)(C=C)C |
| Structure: |
|
| InChiKey: | UWKAYLJWKGQEPM-UHFFFAOYSA-N |
| Molecular Weight: | 196.29 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Enhance lipid metabolism |
| Clinical Trial Progress: | Clinical trial on-going (ISRCTN33165861) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0459 | ISRCTN12833814 | Not applicable | Not Recruiting | No Results Available | 07/08/2019 | 14 September 2020 | Details |
| L0721 | ISRCTN33165861 | Not applicable | Recruiting | No Results Available | 04/11/2019 | 10 December 2019 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A06508 | 32849284 | Front Endocrinol (Lausanne) | Randomized Clinical Trial: Bergamot Citrus and Wild Cardoon Reduce Liver Steatosis and Body Weight in Non-diabetic Individuals Aged Over 50 Years. | Details |
| A06990 | 32670822 | J Tradit Complement Med | The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress in non-alcoholic fatty liver disease. | Details |
| A08574 | 32054943 | Sci Rep | Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease. | Details |
| A10964 | 31101130 | Lipids Health Dis | The effect of bergamot polyphenolic fraction on lipid transfer protein system and vascular oxidative stress in a rat model of hyperlipemia. | Details |
| A12565 | 30388763 | Nutrients | Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by "Junk Food": Evidence for Anti-Inflammatory Activity. | Details |
| A13593 | 29890411 | J Nutr Biochem | Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones. | Details |
| A16463 | 28373762 | World J Gastroenterol | Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. | Details |
| A20332 | 26025327 | J Nutr Biochem | Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome. | Details |
| A49807 | 35631240 | Nutrients | Effect of Dietary Supplementation with Eufortyn® Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of Non-Alcoholic Fatty Liver Disease and Systemic Inflammation in Healthy Subjects with Polygenic Hypercholesterolemia: The ANEMONE Study. | Details |