Investigational Drug Details
| Drug ID: | D301 |
| Drug Name: | Resveratrol |
| Synonyms: | (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol(E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol; (E)-resveratrol; 3,4',5-trihydroxy-trans-stilbene; 3,4',5-trihydroxystilbene; 3,5,4'-trihydroxystilbene; 5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol; trans-resveratrol |
| Type: | Chemical drug |
| DrugBank ID: | DB02709 |
| DrugBank Description: | Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic phytoalexin. It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. It exists as cis-(Z) and trans-(E) isomers. The trans- form can undergo isomerisation to the cis- form when heated or exposed to ultraviolet irradiation. In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. It has been claimed that it is readily degraded by exposure to light, heat, and oxygen. However, studies find that Trans-resveratrol undergoes negligible oxidation in normal atmosphere at room temperature. |
| PubChem ID: | 445154 |
| CasNo: | 501-36-0 |
| Repositioning for NAFLD: | No |
| SMILES: | C(=C\c1ccc(cc1)O)/c1cc(O)cc(c1)O |
| Structure: |
|
| InChiKey: | LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| Molecular Weight: | 228.247 |
| DrugBank Targets: | Ribosyldihydronicotinamide dehydrogenase [quinone]; Casein kinase II subunit alpha; Prostaglandin G/H synthase 1 inhibitor; Prostaglandin G/H synthase 2 inhibitor; Arachidonate 15-lipoxygenase; Arachidonate 5-lipoxygenase; Aryl hydrocarbon receptor; Phosp |
| DrugBank MoA: | Resveratrol suppresses NF-kappaB (NF-kappaB) activation in HSV infected cells. Reports have indicated that HSV activates NF-kappaB during productive infection and this may be an essential aspect of its replication scheme . |
| DrugBank Pharmacology: | Resveratrol, a phytoalexin, has been found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner, although this is only one of its many pharmaceutical properties. In some countries where there is higher consumption of red wine, there appears to be a lower incidence of heart disease. Other benefits of resveratrol include its anti-inflammatory and antioxidant effects. In preclinical studies, Resveratrol has been found to have potential anticancer properties. |
| DrugBank Indication: | Being investigated for the treatment of Herpes labialis infections (cold sores). |
| Targets: | ALOX15; ALOX5; AHR; NR1I2; NR1I3 |
| Therapeutic Category: | Anticancer agent |
| Clinical Trial Progress: | Phase 2&3 completed (NCT02216552) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0645 | IRCT201202014010N7 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 11/01/2013 | 22 February 2018 | Details |
| L0851 | IRCT201511233664N16 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 08/02/2016 | 22 February 2018 | Details |
| L0897 | NCT02216552 | Phase 2/Phase 3 | Not recruiting | No Results Available | 12/08/2014 | 16 December 2017 | Details |
| L0908 | NCT02030977 | Phase 2/Phase 3 | Not recruiting | No Results Available | 29/12/2013 | 19 February 2015 | Details |
| L0927 | ACTRN12612001135808 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 24/10/2012 | 13 January 2020 | Details |
| L0935 | ChiCTR-TRC-12002378 | Pilot study | Not Recruiting | No Results Available | 16/07/2012 | 18 April 2017 | Details |
| L0949 | NCT01446276 | Not applicable | Not recruiting | No Results Available | 03/10/2011 | 19 February 2015 | Details |
| L0951 | NCT01464801 | Not applicable | Not recruiting | No Results Available | 29/09/2011 | 29 June 2015 | Details |
| L1001 | NCT01150955 | Not applicable | Completed | No Results Available | October 2010 | March 22, 2012 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00014 | 35254877 | Arch Physiol Biochem | Resveratrol attenuates against high-fat-diet-promoted non-alcoholic fatty liver disease in rats mainly by targeting the miR-34a/SIRT1 axis. | Details |
| A00017 | 35252807 | iScience | A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease. | Details |
| A00095 | 35221291 | J Pharmacol Exp Ther | Resveratrol attenuates HFD-induced hepatic lipotoxicity by up-regulating Bmi-1 expression. | Details |
| A00221 | 35178496 | APL Bioeng | Development of resveratrol with thiolated alginate as a supplement to prevent nonalcoholic fatty liver disease (NAFLD). | Details |
| A00744 | 34981470 | Adv Exp Med Biol | The Effect of Herbal Medicine and Natural Bioactive Compounds on Plasma Adiponectin: A Clinical Review. | Details |
| A00763 | 34977130 | Front Nutr | Sirt1 Promotes the Restoration of Hepatic Progenitor Cell (HPC)-Mediated Liver Fatty Injury in NAFLD Through Activating the Wnt/β-Catenin Signal Pathway. | Details |
| A00795 | 34964604 | Biomacromolecules | Construction of Glycogen-Based Nanoparticles Loaded with Resveratrol for the Alleviation of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | Details |
| A00850 | 34948230 | Int J Mol Sci | It Is High Time Physicians Thought of Natural Products for Alleviating NAFLD. Is There Sufficient Evidence to Use Them? | Details |
| A00898 | 34935645 | JCI Insight | Maternal Western diet exposure increases periportal fibrosis beginning in utero in nonhuman primate offspring. | Details |
| A01702 | 34650394 | Food Nutr Res | Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague-Dawley rats. | Details |
| A01704 | 34649337 | Biomed Pharmacother | Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology. | Details |
| A02178 | 34473313 | Methods Mol Biol | Therapeutic Effects of Resveratrol on Nonalcoholic Fatty Liver Disease Through Inflammatory, Oxidative Stress, Metabolic, and Epigenetic Modifications. | Details |
| A02182 | 34470993 | J Toxicol Sci | Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring. | Details |
| A02254 | 34445644 | Int J Mol Sci | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome. | Details |
| A02474 | 34360538 | Int J Mol Sci | Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. | Details |
| A02598 | 34320173 | Am J Clin Nutr | The effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trials. | Details |
| A02751 | 34260003 | Neurochem Res | Resveratrol Protects SH-SY5Y Cells Against Oleic Acid-Induced Glucolipid Metabolic Dysfunction and Cell Injuries Via the Wnt/β-Catenin Signalling Pathway. | Details |
| A03265 | 34065444 | Nutrients | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset. | Details |
| A03460 | 33992930 | Eur J Med Chem | Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview. | Details |
| A03754 | 33877249 | Food Funct | Pterostilbene modifies triglyceride metabolism in hepatic steatosis induced by high-fat high-fructose feeding: a comparison with its analog resveratrol. | Details |