Investigational Drug Details
| Drug ID: | D345 |
| Drug Name: | Spirulina |
| Synonyms: | Arthrospira platensis; Arthrospira platensis whole; Oscillatoria platensis; Spirulina; Spirulina (arthrospira platensis); Spirulina platensis; Spirulina platensis whole |
| Type: | Biological drug |
| DrugBank ID: | DB14744 |
| DrugBank Description: | -- |
| PubChem ID: | 91864513 |
| CasNo: | 1087037-76-0 |
| Repositioning for NAFLD: | No |
| SMILES: | O([C@@H](/C=C/C(=C/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C1=C(C)C[C@H](CC1(C)C)O)\C)\C)/C)/C)/C)C(C)(C)O)[C@H]1[C@H](O)[C@H](O)[C@H]([C@@H](O1)C)O |
| Structure: |
|
| InChiKey: | MUCOHWBULSBLLZ-ALZSAHPVSA-N |
| Molecular Weight: | 731.027 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Prebiotics |
| Clinical Trial Progress: | Clinical trial on-going (IRCT20200304046692N1) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0536 | IRCT20200304046692N1 | Not applicable | Not Recruiting | No Results Available | 11/03/2020 | 24 March 2020 | Details |
| L0862 | IRCT2014121620345N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 19/10/2015 | 22 February 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00275 | 35154670 | Food Sci Nutr | The effect of Spirulina sauce, as a functional food, on cardiometabolic risk factors, oxidative stress biomarkers, glycemic profile, and liver enzymes in nonalcoholic fatty liver disease patients: A randomized double-blinded clinical trial. | Details |
| A00850 | 34948230 | Int J Mol Sci | It Is High Time Physicians Thought of Natural Products for Alleviating NAFLD. Is There Sufficient Evidence to Use Them? | Details |
| A06649 | 32795119 | Metab Syndr Relat Disord | Omeprazole and Spirulina Platensis Ameliorate Steatohepatitis in Experimental Nonalcoholic Fatty Liver Disease. | Details |
| A10725 | 31220177 | PLoS One | Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice. | Details |
| A11646 | 30806344 | Br J Nutr | Spirulina supplementation in a mouse model of diet-induced liver fibrosis reduced the pro-inflammatory response of splenocytes. | Details |
| A11955 | 30669332 | Nutrients | Spirulina Liquid Extract Protects against Fibrosis Related to Non-Alcoholic Steatohepatitis and Increases Ursodeoxycholic Acid. | Details |
| A14259 | 29499310 | Neurosci Lett | Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1-42 (Aβ1-42) induced neurotoxicity in PC12 cells. | Details |
| A15973 | 28632181 | Nutrients | Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota? | Details |
| A16276 | 28472600 | J Med Food | Glucomannan or Glucomannan Plus Spirulina-Enriched Squid-Surimi Diets Reduce Histological Damage to Liver and Heart in Zucker fa/fa Rats Fed a Cholesterol-Enriched and Non-Cholesterol-Enriched Atherogenic Diet. | Details |
| A21240 | 25460293 | Horm Mol Biol Clin Investig | Nutrition: a promising route for prevention and management of obesity-related nonalcoholic fatty liver disease. | Details |
| A21422 | 25331487 | Ann Gastroenterol | The hepatoprotective and hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population with non-alcoholic fatty liver disease: a prospective pilot study. | Details |
| A21497 | 25274101 | Br J Nutr | Non-alcoholic fatty liver disease: need for a balanced nutritional source. | Details |
| A24836 | 22444524 | Dig Liver Dis | Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome. | Details |
| A25502 | 21764223 | Med Hypotheses | Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease. | Details |
| A25660 | 21569626 | Lipids Health Dis | Exercise and spirulina control non-alcoholic hepatic steatosis and lipid profile in diabetic Wistar rats. | Details |
| A26514 | 20370930 | J Med Case Rep | Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case series. | Details |
| A34575 | 23170052 | J Clin Biochem Nutr | Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis. | Details |
| A48533 | 34616107 | J Clin Biochem Nutr | Spirulina platensis and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model. | Details |