Investigational Drug Details
| Drug ID: | D348 |
| Drug Name: | Stanol |
| Synonyms: | -- |
| Type: | Biological extract |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | 127121-08-8 |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (NCT03627819) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0791 | NCT03627819 | Not applicable | Not recruiting | No Results Available | 18/07/2018 | 12 December 2020 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A07886 | 32323115 | Eur J Epidemiol | Adherence to a plant-based, high-fibre dietary pattern is related to regression of non-alcoholic fatty liver disease in an elderly population. | Details |
| A07907 | 32315005 | Food Funct | Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms. | Details |
| A11605 | 30822462 | Prog Lipid Res | Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?" | Details |
| A12750 | 30303744 | FASEB J | Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis. | Details |
| A12790 | 30287500 | Biosci Rep | Comment on Tauriainen et al.: Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD. | Details |
| A13526 | 29930468 | World J Gastroenterol | Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. | Details |
| A14188 | 29540533 | Biosci Rep | Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD. | Details |
| A21383 | 25356831 | PLoS One | Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans. | Details |
| A26179 | 20947198 | J Hepatol | Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. | Details |
| A28375 | 15336441 | J Hepatol | A novel aminosterol reverses diabetes and fatty liver disease in obese mice. | Details |
| A30519 | 32291331 | J Lipid Res | Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease. | Details |
| A32173 | 29057935 | Sci Rep | Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice. | Details |
| A45658 | 23409094 | PLoS One | Dietary sphingomyelin lowers hepatic lipid levels and inhibits intestinal cholesterol absorption in high-fat-fed mice. | Details |