Investigational Drug Details
| Drug ID: | D354 |
| Drug Name: | Sulforaphane |
| Synonyms: | (-)-sulforaphane; (R)-sulforaphane; 4-methylsulfinylbutyl isothiocyanate |
| Type: | Chemical drug |
| DrugBank ID: | DB12422 |
| DrugBank Description: | Sulforaphane is under investigation for the treatment of Autism Spectrum Disorder. It is a naturally occurring isothiocyanate found in high concentration in a variety of broccoli. |
| PubChem ID: | 5350 |
| CasNo: | 4478-93-7 |
| Repositioning for NAFLD: | No |
| SMILES: | C(CCN=C=S)CS(=O)C |
| Structure: |
|
| InChiKey: | SUVMJBTUFCVSAD-UHFFFAOYSA-N |
| Molecular Weight: | 177.294 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Anticarcinogenic, Antineoplastic, Antioxidant |
| Clinical Trial Progress: | Clinical trial on-going (NCT04364360) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0704 | NCT04364360 | Not applicable | Recruiting | No Results Available | 06/04/2020 | 10 May 2021 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00665 | 35010950 | Nutrients | Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. | Details |
| A01498 | 34722615 | Front Nutr | Role of the Aryl Hydrocarbon Receptor and Gut Microbiota-Derived Metabolites Indole-3-Acetic Acid in Sulforaphane Alleviates Hepatic Steatosis in Mice. | Details |
| A01537 | 34706542 | J Agric Food Chem | Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways. | Details |
| A01685 | 34654875 | Acta Pharmacol Sin | Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway. | Details |
| A03162 | 34107274 | Exp Cell Res | Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway. | Details |
| A03886 | 33833347 | Sci Rep | Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis. | Details |
| A04489 | 33598160 | Food Sci Nutr | The protective effect of sulforaphane on type II diabetes induced by high-fat diet and low-dosage streptozotocin. | Details |
| A07696 | 32388251 | J Nutr Biochem | Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane. | Details |
| A09369 | 31775341 | Int J Mol Sci | Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction. | Details |
| A12157 | 30578708 | Mol Nutr Food Res | Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro. | Details |
| A13577 | 29898626 | Adipocyte | Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance. | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | Details |
| A15819 | 28694655 | World J Gastroenterol | Antioxidant dietary approach in treatment of fatty liver: New insights and updates. | Details |
| A16752 | 28209760 | Diabetes | Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. | Details |
| A17669 | 27672403 | J Funct Foods | Dietary broccoli protects against fatty liver development but not against progression of liver cancer in mice pretreated with diethylnitrosamine. | Details |
| A18519 | 27075683 | Sci Rep | A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet. | Details |
| A25723 | 21504366 | Antioxid Redox Signal | Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding. | Details |
| A43790 | 30879091 | Cell Mol Life Sci | Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. | Details |
| A49359 | 35779187 | Cell Stress Chaperones | Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats. | Details |