Investigational Drug Details
| Drug ID: | D356 |
| Drug Name: | Symbiotic |
| Synonyms: | -- |
| Type: | Biological drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 2&3 on-going (NCT02530138) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0869 | NCT02530138 | Phase 2/Phase 3 | Recruiting | No Results Available | 18/08/2015 | 31 August 2015 | Details |
| L0907 | IRCT2013122811763N15 | Not applicable | Not Recruiting | No Results Available | 02/01/2014 | 22 February 2018 | Details |
| L0924 | NCT01791959 | Phase 2/Phase 3 | Not recruiting | No Results Available | 05/02/2013 | 19 February 2015 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00851 | 34948020 | Int J Mol Sci | The New Therapeutic Approaches in the Treatment of Non-Alcoholic Fatty Liver Disease. | Details |
| A02001 | 34533882 | Cancer Sci | Gut-liver axis-mediated mechanism of liver cancer: A special focus on the role of gut microbiota. | Details |
| A02284 | 34437908 | J Hepatol | Intestinal virome and therapeutic potential of bacteriophages in liver disease. | Details |
| A02892 | 34204274 | Int J Mol Sci | Nonalcoholic Fatty Liver Disease (NAFLD) as Model of Gut-Liver Axis Interaction: From Pathophysiology to Potential Target of Treatment for Personalized Therapy. | Details |
| A03766 | 33871224 | Minerva Gastroenterol (Torino) | Gut microbiota and non-alcoholic fatty liver disease. | Details |
| A04600 | 33567710 | Int J Environ Res Public Health | Nutritional Approach Targeting Gut Microbiota in NAFLD-To Date. | Details |
| A11983 | 30658519 | Int J Mol Sci | Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature. | Details |
| A12117 | 32864300 | Curr Pharmacol Rep | Dietary Additives and Supplements Revisited: The Fewer, the Safer for Liver and Gut Health. | Details |
| A12159 | 30578461 | Adv Exp Med Biol | Fighting Fatty Liver Diseases with Nutritional Interventions, Probiotics, Symbiotics, and Fecal Microbiota Transplantation (FMT). | Details |
| A13150 | 30113661 | Nutr Rev | Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis. | Details |
| A13994 | 29653359 | J Nutr Biochem | The role of the gut microbiota in the pathology and prevention of liver disease. | Details |
| A15228 | 29035308 | Nutrients | Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanisms and Therapy. | Details |
| A15259 | 29019564 | Arq Bras Cir Dig | THE IMPACT OF THE USE OF SYMBIOTICS IN THE PROGRESSION OF NONALCOHOLIC FATTY LIVER DISEASE IN A RAT MODEL. | Details |
| A15422 | 28921469 | Adv Exp Med Biol | Microbial Factors in Inflammatory Diseases and Cancers. | Details |
| A16203 | 28507473 | EXCLI J | Effects of symbiotic and vitamin E supplementation on blood pressure, nitric oxide and inflammatory factors in non-alcoholic fatty liver disease. | Details |
| A16677 | 28250783 | J Res Med Sci | Do symbiotic and Vitamin E supplementation have favorite effects in nonalcoholic fatty liver disease? A randomized, double-blind, placebo-controlled trial. | Details |
| A17235 | 27895587 | Front Physiol | Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. | Details |
| A17278 | 27866836 | Cell Metab | Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. | Details |
| A18516 | 27076897 | Int J Prev Med | The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial. | Details |
| A18632 | 27023533 | Int J Mol Sci | Gut Microbiota and Lifestyle Interventions in NAFLD. | Details |