Investigational Drug Details
| Drug ID: | D374 |
| Drug Name: | Trehalose |
| Synonyms: | Cabaletta |
| Type: | Chemical drug |
| DrugBank ID: | DB12310 |
| DrugBank Description: | Cabaletta has been used in trials studying the treatment of Oculopharyngeal Muscular Dystrophy. |
| PubChem ID: | 7427 |
| CasNo: | 99-20-7 |
| Repositioning for NAFLD: | No |
| SMILES: | O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O)[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O |
| Structure: |
|
| InChiKey: | HDTRYLNUVZCQOY-LIZSDCNHSA-N |
| Molecular Weight: | 342.297 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial completed (NCT03738358) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0782 | NCT03738358 | Not applicable | Not recruiting | No Results Available | 08/11/2018 | 12 December 2020 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A07867 | 32329657 | Gut Microbes | Microbial and metabolic impacts of trehalose and trehalose analogues. | Details |
| A08191 | 32212870 | Expert Rev Endocrinol Metab | Nonalcoholic fatty liver disease, insulin resistance, and sweeteners: a literature review. | Details |
| A09201 | 31838076 | Gastroenterology | Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. | Details |
| A11277 | 30962478 | Nat Commun | Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting. | Details |
| A11354 | 30925684 | Int J Mol Sci | The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice. | Details |
| A25557 | 21713513 | Appl Microbiol Biotechnol | Large-scale expression, purification, and glucose uptake activity of recombinant human FGF21 in Escherichia coli. | Details |
| A30256 | 32733451 | Front Immunol | The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease. | Details |
| A42456 | 34486131 | Alcohol Clin Exp Res | Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. | Details |
| A44902 | 26905424 | Sci Signal | Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport. | Details |
| A50756 | 35276968 | Nutrients | Metabolism and Health Effects of Rare Sugars in a CACO-2/HepG2 Coculture Model. | Details |