Investigational Drug Details
| Drug ID: | D038 |
| Drug Name: | Biguanide |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | DB13100 |
| DrugBank Description: | Biguanide has been investigated for the treatment of Diabetes Mellitus. |
| PubChem ID: | 5939 |
| CasNo: | 56-03-1 |
| Repositioning for NAFLD: | Yes |
| SMILES: | N(C(=N)N)C(=N)N |
| Structure: |
|
| InChiKey: | XNCOSPRUTUOJCJ-UHFFFAOYSA-N |
| Molecular Weight: | 101.113 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (CTRI/2019/03/018039) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01811 | 34606980 | Endocr Pract | Antidiabetic Medications for Type 2 Diabetics with Nonalcoholic Fatty Liver Disease: Evidence From a Network Meta-Analysis of Randomized Controlled Trials. | Details |
| A09439 | 31749893 | Diabetol Metab Syndr | Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats. | Details |
| A10018 | 31523440 | BMJ Open Gastroenterol | Real-world comorbidities and treatment patterns among patients with non-alcoholic fatty liver disease receiving phosphatidylcholine as adjunctive therapy in Russia. | Details |
| A12039 | 30628769 | ACS Appl Mater Interfaces | Targeted Interleukin-22 Gene Delivery in the Liver by Polymetformin and Penetratin-Based Hybrid Nanoparticles to Treat Nonalcoholic Fatty Liver Disease. | Details |
| A12223 | 30556145 | Hepatology | Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease. | Details |
| A12514 | 30413050 | Pharmaceuticals (Basel) | Antidiabetic Drugs in NAFLD: The Accomplishment of Two Goals at Once? | Details |
| A12888 | 30241400 | Int J Mol Sci | Metformin: An Old Drug with New Applications. | Details |
| A17162 | 27939359 | Pharmacol Res | A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug? | Details |
| A20122 | 26140084 | World J Hepatol | Systematic review: Preventive and therapeutic applications of metformin in liver disease. | Details |
| A22122 | 24799988 | World J Hepatol | Insulin sensitizers for the treatment of non-alcoholic fatty liver disease. | Details |
| A22371 | 24633023 | Intern Med | Estimation of visceral fat and fatty liver disease using ultrasound in patients with diabetes. | Details |
| A24655 | 25755424 | J Clin Exp Hepatol | Management of Non-alcoholic Fatty Liver Disease and Steatohepatitis. | Details |
| A25499 | 21765869 | Therap Adv Gastroenterol | The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis. | Details |
| A26709 | 19921118 | Adv Ther | Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status. | Details |
| A28059 | 16540770 | J Clin Gastroenterol | Therapy of NAFLD: insulin sensitizing agents. | Details |
| A28079 | 16672828 | J Clin Gastroenterol | Therapy of NAFLD: Insulin Sensitizing Agents. | Details |
| A28165 | 16231594 | Eur Rev Med Pharmacol Sci | The treatment of NAFLD. | Details |
| A36989 | 16768125 | Nihon Rinsho | [Insulin sensitizer--anti-diabetic drugs, metformin and pioglitazone that can improve insulin resistance]. | Details |
| A36990 | 16768123 | Nihon Rinsho | [Drug therapy for non-alcoholic steatohepatitis]. | Details |
| A44501 | 28459036 | Indian J Endocrinol Metab | Consensus Statement on Dose Modifications of Antidiabetic Agents in Patients with Hepatic Impairment. | Details |