Investigational Drug Details
Drug ID: | D386 |
Drug Name: | Vitamin C |
Synonyms: | Ascorbate; Ascorbic acid; L-(+)-ascorbic acid; L-Ascorbate; L-Ascorbic Acid; Vitamin C |
Type: | Supplement |
DrugBank ID: | DB00126 |
DrugBank Description: | A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. |
PubChem ID: | 54670067 |
CasNo: | 50-81-7 |
Repositioning for NAFLD: | Yes |
SMILES: | [C@@H](CO)(O)[C@@H]1C(=C(C(=O)O1)O)O |
Structure: |
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InChiKey: | CIWBSHSKHKDKBQ-JLAZNSOCSA-N |
Molecular Weight: | 176.124 |
DrugBank Targets: | Hyaluronate lyase inhibitor; DNA cleavage; Xylose isomerase substrate; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 cofactor; Phytanoyl-CoA dioxygenase, peroxisomal cofactor; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 cofactor; Gamma-butyrobet |
DrugBank MoA: | In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration. |
DrugBank Pharmacology: | Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency. |
DrugBank Indication: | Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent. |
Targets: | PLOD2 cofactor; PLOD3 cofactor; DBH cofactor; P3H1 cofactor; P3H2 cofactor; P3H3 cofactor; PLOD1 cofactor |
Therapeutic Category: | -- |
Clinical Trial Progress: | Phase 0 on-going (ChiCTR2000033171) |
Latest Progress: | Under clinical trials |

Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
---|---|---|---|---|---|---|---|
L0427 | ChiCTR2000033171 | Phase 0 | Not Recruiting | No Results Available | 22/05/2020 | 25 May 2020 | Details |
L0586 | ChiCTR-IPR-16008156 | Pilot study | Recruiting | No Results Available | 25/03/2016 | 18 April 2017 | Details |
L0622 | IRCT201408312709N29 | Phase 3 | Not Recruiting | No Results Available | 11/10/2014 | 22 February 2018 | Details |
L0927 | ACTRN12612001135808 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 24/10/2012 | 13 January 2020 | Details |
L0993 | NCT00862433 | Phase 1 | Recruiting | No Results Available | October 10, 2014 | April 6, 2022 | Details |
Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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Article ID | PMID | Source | Title | |
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A00198 | 35189786 | Scand J Gastroenterol | Association of serum vitamin C with liver fibrosis in adults with nonalcoholic fatty liver disease. | Details |
A00206 | 35187020 | Front Nutr | Association of Serum Vitamin C With NAFLD and MAFLD Among Adults in the United States. | Details |
A00231 | 35174195 | Front Nutr | Dietary Vitamin C Intake Is Associated With Improved Liver Function and Glucose Metabolism in Chinese Adults. | Details |
A00543 | 35052573 | Antioxidants (Basel) | Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig. | Details |
A01100 | 34869532 | Front Nutr | Clinical Relevance of Vitamins and Carotenoids With Liver Steatosis and Fibrosis Detected by Transient Elastography in Adults. | Details |
A01816 | 34606532 | Food Funct | Beneficial impacts of fermented celery (Apium graveolens L.) juice on obesity prevention and gut microbiota modulation in high-fat diet fed mice. | Details |
A01840 | 34595203 | Front Nutr | Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. | Details |
A02042 | 34522493 | Cureus | The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review. | Details |
A02761 | 34255575 | Metab Syndr Relat Disord | Relationship Between Protein Intake and Sarcopenia in the Elderly with Nonalcoholic Fatty Liver Disease Based on the Fourth and Fifth Korea National Health and Nutrition Examination Survey. | Details |
A02844 | 34221537 | Liver Res | Vitamins and non-alcoholic fatty liver disease: A Molecular Insight⋆. | Details |
A02888 | 34204849 | Antioxidants (Basel) | Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs' Livers. | Details |
A03112 | 34126083 | Am J Pathol | Vitamin C Deficiency Inhibits Nonalcoholic Fatty Liver Disease Progression through Impaired de Novo Lipogenesis. | Details |
A05694 | 33152949 | Biomed Pharmacother | Prophylactic and therapeutic effects of different doses of vitamin C on high-fat-diet-induced non-alcoholic fatty liver disease in mice. | Details |
A05903 | 33080906 | Medicina (Kaunas) | Silymarin in Combination with Vitamin C, Vitamin E, Coenzyme Q10 and Selenomethionine to Improve Liver Enzymes and Blood Lipid Profile in NAFLD Patients. | Details |
A06129 | 32995080 | PeerJ | Association between serum and dietary antioxidant micronutrients and advanced liver fibrosis in non-alcoholic fatty liver disease: an observational study. | Details |
A06483 | 32862731 | Int J Food Sci Nutr | Dietary calamondin supplementation slows the progression of non-alcoholic fatty liver disease in C57BL/6 mice fed a high-fat diet. | Details |
A10066 | 31504822 | Nutr Rev | Role of fruit juice in achieving the 5-a-day recommendation for fruit and vegetable intake. | Details |
A10475 | 31322211 | Mol Med Rep | Ascorbic acid attenuates cell stress by activating the fibroblast growth factor 21/fibroblast growth factor receptor 2/adiponectin pathway in HepG2 cells. | Details |
A10581 | 31281067 | Dig Liver Dis | Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease. | Details |
A10961 | 31101782 | Georgian Med News | COMPARATIVE ANALYSIS OF EFFICIENCY OF URSODEOXYCHOLIC ACID AND COMBINATION OF VITAMIN E AND VITAMIN C IN TREATMENT OF NON-DIABETIC NONALCOHOLIC STEATOHEPATITIS. | Details |