Investigational Drug Details

Drug ID: D386
Drug Name: Vitamin C
Synonyms: Ascorbate; Ascorbic acid; L-(+)-ascorbic acid; L-Ascorbate; L-Ascorbic Acid; Vitamin C
Type: Supplement
DrugBank ID: DB00126
DrugBank Description: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
PubChem ID: 54670067
CasNo: 50-81-7
Repositioning for NAFLD: Yes
SMILES: [C@@H](CO)(O)[C@@H]1C(=C(C(=O)O1)O)O
Structure:
InChiKey: CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Molecular Weight: 176.124
DrugBank Targets: Hyaluronate lyase inhibitor; DNA cleavage; Xylose isomerase substrate; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 cofactor; Phytanoyl-CoA dioxygenase, peroxisomal cofactor; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 cofactor; Gamma-butyrobet
DrugBank MoA: In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.
DrugBank Pharmacology: Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency.
DrugBank Indication: Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
Targets: PLOD2 cofactor; PLOD3 cofactor; DBH cofactor; P3H1 cofactor; P3H2 cofactor; P3H3 cofactor; PLOD1 cofactor
Therapeutic Category: --
Clinical Trial Progress: Phase 0 on-going (ChiCTR2000033171)
Latest Progress: Under clinical trials

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