Investigational Drug Details
| Drug ID: | D482 |
| Drug Name: | Heme Oxygenase |
| Synonyms: | -- |
| Type: | Biological drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (NCT00842205) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0358 | NCT00842205 | Not applicable | Unknown status | No Results Available | January 2007 | February 12, 2009 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00472 | 35068798 | J Clin Exp Hepatol | Diagnosis and Management of Cirrhotic Cardiomyopathy. | Details |
| A00882 | 34943103 | Antioxidants (Basel) | Association of Serum Bilirubin and Functional Variants of Heme Oxygenase 1 and Bilirubin UDP-Glucuronosyl Transferase Genes in Czech Adult Patients with Non-Alcoholic Fatty Liver Disease. | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | Details |
| A02455 | 34365685 | FASEB J | Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. | Details |
| A02594 | 34321089 | Stem Cell Res Ther | Addressing the liver progenitor cell response and hepatic oxidative stress in experimental non-alcoholic fatty liver disease/non-alcoholic steatohepatitis using amniotic epithelial cells. | Details |
| A02787 | 34240649 | Int J Immunopathol Pharmacol | Allopurinol ameliorates liver injury in type 1 diabetic rats through activating Nrf2. | Details |
| A03474 | 33990765 | Acta Pharmacol Sin | Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. | Details |
| A03643 | 33922045 | Molecules | Protective Effect of Cudrania tricuspidata Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway. | Details |
| A03702 | 33898958 | JHEP Rep | Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD. | Details |
| A03752 | 33878116 | PLoS One | Leaf powder supplementation of Senna alexandrina ameliorates oxidative stress, inflammation, and hepatic steatosis in high-fat diet-fed obese rats. | Details |
| A03871 | 33838229 | J Nutr Biochem | Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease. | Details |
| A03955 | 33808635 | Nutrients | Role of HO-1 against Saturated Fatty Acid-Induced Oxidative Stress in Hepatocytes. | Details |
| A04518 | 33590347 | J Nat Med | Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis. | Details |
| A04951 | 33439102 | Am J Physiol Gastrointest Liver Physiol | Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | Details |
| A05060 | 33390979 | Front Pharmacol | Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate. | Details |
| A05240 | 33327438 | Int J Mol Sci | Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease. | Details |
| A05268 | 33318872 | J Adv Res | Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. | Details |
| A05462 | 33248947 | Arch Biochem Biophys | The pivotal role of heme Oxygenase-1 in reversing the pathophysiology and systemic complications of NAFLD. | Details |
| A06050 | 33027743 | Biomed Pharmacother | Sagittaria sagittifolia polysaccharide interferes with arachidonic acid metabolism in non-alcoholic fatty liver disease mice via Nrf2/HO-1 signaling pathway. | Details |