Investigational Drug Details
| Drug ID: | D513 |
| Drug Name: | VK2809 |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | DB15137 |
| DrugBank Description: | VK-2809 is under investigation in clinical trial NCT02927184 (Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease). |
| PubChem ID: | -- |
| CasNo: | 852948-13-1 |
| Repositioning for NAFLD: | No |
| SMILES: | CC(C)C1=CC(CC2=C(C)C=C(OC[P@@]3(=O)OCC[C@H](O3)C3=CC=CC(Cl)=C3)C=C2C)=CC=C1O |
| Structure: |
|
| InChiKey: | LGGPZDRLTDGYSQ-JADSYQMUSA-N |
| Molecular Weight: | 514.98 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | THR-β agonist |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 2 completed (NCT02927184) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0131 | NCT02927184 | Phase 2 | Completed | No Results Available | September 28, 2016 | April 26, 2021 | Details |
| L0281 | NCT04173065 | Phase 2 | Recruiting | No Results Available | November 15, 2019 | March 3, 2022 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A05309 | 33306682 | PLoS One | Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH). | Details |
| A06825 | 32733906 | Front Med (Lausanne) | Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders. | Details |
| A08469 | 32098589 | Thyroid | Thyroid Hormone Analogues: An Update. | Details |
| A43591 | 31337282 | Thyroid | A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia. | Details |