Investigational Drug Details
| Drug ID: | D546 |
| Drug Name: | Proanthocyanidins |
| Synonyms: | -- |
| Type: | Biological extract |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (ChiCTR-IPR-16008156) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0586 | ChiCTR-IPR-16008156 | Pilot study | Recruiting | No Results Available | 25/03/2016 | 18 April 2017 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A02927 | 34195217 | Front Nutr | Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation. | Details |
| A06492 | 32856322 | J Pharm Pharmacol | Therapeutic effects of açaí seed extract on hepatic steatosis in high-fat diet-induced obesity in male mice: a comparative effect with rosuvastatin. | Details |
| A07253 | 32566176 | Food Sci Nutr | Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice. | Details |
| A11574 | 30833801 | World J Gastroenterol | Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease via the modulation of the gut microbiota in rabbits. | Details |
| A12789 | 30287733 | Nutrients | Achacha (Garcinia humilis) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome. | Details |
| A13090 | 30142454 | Free Radic Biol Med | Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state. | Details |
| A14892 | 29189132 | Curr Pharm Des | Polyphenols: Novel Signaling Pathways. | Details |
| A20008 | 26207852 | J Agric Food Chem | Inhibition of Advanced Glycation Endproduct Formation by Lotus Seedpod Oligomeric Procyanidins through RAGE-MAPK Signaling and NF-κB Activation in High-Fat-Diet Rats. | Details |
| A22259 | 24712752 | J Med Food | Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation. | Details |
| A22783 | 24307947 | J Lipids | Grape seed proanthocyanidin rescues rats from steatosis: a comparative and combination study with metformin. | Details |
| A25034 | 22227333 | Eur J Pharmacol | Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. | Details |
| A25233 | 22067945 | Lipids Health Dis | Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice. | Details |
| A46982 | 31336037 | Mol Nutr Food Res | The Preventative Effects of Procyanidin on Binge Ethanol-Induced Lipid Accumulation and ROS Overproduction via the Promotion of Hepatic Autophagy. | Details |
| A50627 | 35322435 | J Food Biochem | Chia seeds and chemical-elicited sprouts supplementation ameliorates insulin resistance, dyslipidemia, and hepatic steatosis in obese rats. | Details |
| A51877 | 33499382 | Nutrients | Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats. | Details |
| A52264 | 29502000 | Environ Pollut | Dietary grape seed proanthocyanidin extract regulates metabolic disturbance in rat liver exposed to lead associated with PPARα signaling pathway. | Details |
| A52877 | 20332082 | Mol Cell Proteomics | Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet. | Details |