Investigational Drug Details
| Drug ID: | D610 |
| Drug Name: | Thalidomide |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | Tumour necrosis factor inhibitors |
| Therapeutic Category: | Antifibrotics; Antileprotics; Antineoplastics; Anti-inflammatory |
| Clinical Trial Progress: | -- |
| Latest Progress: | Under investigation |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A26615 | 20088867 | Liver Int | The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. | Details |
| A31276 | 30909602 | Cells | 2,4 Dinitrophenol as Medicine. | Details |
| A45116 | 26033770 | Birth Defects Res A Clin Mol Teratol | Multicenter investigation of lifestyle-related diseases and visceral disorders in thalidomide embryopathy at around 50 years of age. | Details |
| A48318 | 16803426 | Pharmacotherapy | Thalidomide-induced severe hepatotoxicity. | Details |