Investigational Drug Details
| Drug ID: | D611 |
| Drug Name: | Infliximab |
| Synonyms: | GS 071; NI-071 |
| Type: | Biological drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | Tumour necrosis factor alpha inhibitors |
| Therapeutic Category: | Anti-inflammatories |
| Clinical Trial Progress: | -- |
| Latest Progress: | Under investigation |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A07718 | 32377366 | BMJ Open Gastroenterol | Antitumour necrosis factor-α agents and development of new-onset cirrhosis or non-alcoholic fatty liver disease: a retrospective cohort. | Details |
| A10121 | 31474792 | Ann Gastroenterol | High prevalence of non-alcoholic fatty liver disease in patients with inflammatory bowel disease receiving anti-tumor necrosis factor therapy. | Details |
| A12536 | 30403898 | J Dermatolog Treat | Successful therapy of plaque-type psoriasis with secukinumab in patients with multiple comorbidities treated with previous biologic therapies. | Details |
| A13261 | 30060508 | Int J Mol Sci | Harmful Effects and Potential Benefits of Anti-Tumor Necrosis Factor (TNF)-α on the Liver. | Details |
| A16810 | 28160250 | Curr Treat Options Gastroenterol | Thiopurines and Methotrexate Use in IBD Patients in a Biologic Era. | Details |
| A16908 | 28099601 | An Bras Dermatol | Psoriasis comorbidities: complications and benefits of immunobiological treatment. | Details |
| A20527 | 25910299 | Turk J Gastroenterol | A comparison of the effects of infliximab, adalimumab, and pentoxifylline on rats with non-alcoholic steatohepatitis. | Details |
| A22533 | 24486698 | Mol Cell Endocrinol | Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: an experimental study in the rabbit. | Details |
| A22878 | 24259964 | World J Gastroenterol | Hepatobiliary manifestations in inflammatory bowel disease: the gut, the drugs and the liver. | Details |
| A24976 | 22288305 | Eur Rev Med Pharmacol Sci | The psoriatic patient profile for infliximab. | Details |
| A27560 | 18066656 | Inflammation | The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. | Details |
| A27650 | 17761893 | J Endocrinol | Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. | Details |
| A47018 | 29708448 | Expert Opin Pharmacother | Alcoholic steatohepatitis (ASH) and alcoholic hepatitis (AH): cascade of events, clinical aspects, and pharmacotherapy options. | Details |
| A47052 | 27824131 | Sci Rep | Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice. | Details |
| A47161 | 24656653 | Gastroenterol Hepatol | Alcoholic hepatitis: Prognosis and treatment. | Details |
| A47201 | 23025051 | Eksp Klin Farmakol | [Hepatoprotective and immunomodulatory effects of infliximab on experimental alcoholic steatohepatitis]. | Details |
| A47319 | 17203086 | Nat Clin Pract Gastroenterol Hepatol | Management strategies in alcoholic liver disease. | Details |
| A47337 | 16115302 | J Intern Med | Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis. | Details |
| A51609 | 35679608 | J Crohns Colitis | Faecal metabolomics in paediatric inflammatory bowel disease: a systematic review. | Details |