Investigational Drug Details
| Drug ID: | D072 |
| Drug Name: | Chitosan |
| Synonyms: | Poliglusam low molecular weight (20-200 mpa.s) |
| Type: | Chemical drug |
| DrugBank ID: | DB14155 |
| DrugBank Description: | -- |
| PubChem ID: | 71853 |
| CasNo: | 9012-76-4 |
| Repositioning for NAFLD: | No |
| SMILES: | O([C@H]1[C@H](O)[C@@H](N)[C@H](O[C@H]2[C@H](O)[C@@H](NC(=O)OC)[C@@H](O[C@@H]2CO)O[C@H]2[C@H](O)[C@@H](N)[C@@H](O[C@@H]2CO)O[C@H]2[C@H](O)[C@@H](N)[C@@H](O[C@@H]2CO)O)O[C@@H]1CO)[C@@H]1O[C@@H]([C@@H](O[C@@H]2O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5N)CO)[C@H](O)[C@H]4N)CO)[C@H](O)[C@H]3N)CO)[C@H](O)[C@H]2N)CO)[C@H](O)[C@H]1N)CO |
| Structure: |
|
| InChiKey: | FLASNYPZGWUPSU-SICDJOISSA-N |
| Molecular Weight: | 1526.464 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (IRCT20180412039284N2) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0492 | IRCT20180412039284N2 | Not applicable | Not Recruiting | No Results Available | 19/07/2018 | 11 September 2018 | Details |
| L0500 | IRCT20180412039284N1 | Not applicable | Not Recruiting | No Results Available | 09/05/2018 | 18 June 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00205 | 35187676 | J Food Biochem | Chitosan oligosaccharide attenuates hepatic steatosis in HepG2 cells via the activation of AMP-activated protein kinase. | Details |
| A06028 | 33035588 | Life Sci | Nicotinamide and ascorbic acid nanoparticles against the hepatic insult induced in rats by high fat high fructose diet: A comparative study. | Details |
| A09314 | 31793675 | J Food Biochem | Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters. | Details |
| A09449 | 31744059 | Mar Drugs | Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice. | Details |
| A10619 | 31269758 | Mar Drugs | Chitosan Oligosaccharide Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Mice. | Details |
| A12039 | 30628769 | ACS Appl Mater Interfaces | Targeted Interleukin-22 Gene Delivery in the Liver by Polymetformin and Penetratin-Based Hybrid Nanoparticles to Treat Nonalcoholic Fatty Liver Disease. | Details |
| A13022 | 30176941 | J Nanobiotechnology | Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD. | Details |
| A14527 | 29367486 | J Oleo Sci | Improvement of Diet-induced Obesity by Ingestion of Mushroom Chitosan Prepared from Flammulina velutipes. | Details |
| A18491 | 27095767 | Zhonghua Gan Zang Bing Za Zhi | [Effect of chitooligosaccharide on hepatic triglyceride metabolism and related mechanisms]. | Details |
| A25421 | 21875072 | J Agric Food Chem | Synthesis of carboxymethylated and quaternized chitosans and their therapeutic effect on nonalcoholic Fatty liver disease. | Details |
| A27317 | 18654934 | Scand J Gastroenterol | Chitosan ameliorates the severity of steatohepatitis induced by high fat diet in rats. | Details |
| A34612 | 23060506 | J Wildl Dis | Mucosal adjuvants to improve wildlife rabies vaccination. | Details |
| A34659 | 22976475 | J Mater Sci Mater Med | Development of poly(vinyl acetate-methylacrylic acid)/chitosan/Fe3O4 nanoparticles for the diagnosis of non-alcoholic steatohepatitis with magnetic resonance imaging. | Details |
| A49498 | 35736186 | Mar Drugs | Marine Chitooligosaccharide Alters Intestinal Flora Structure and Regulates Hepatic Inflammatory Response to Influence Nonalcoholic Fatty Liver Disease. | Details |
| A50262 | 35450649 | Carbohydr Polym | Responsive oligochitosan nano-vesicles with ursodeoxycholic acid and exenatide for NAFLD synergistic therapy via SIRT1. | Details |
| A52212 | 30060615 | Mar Drugs | Functional Comparison of High and Low Molecular Weight Chitosan on Lipid Metabolism and Signals in High-Fat Diet-Fed Rats. | Details |