Investigational Drug Details
| Drug ID: | D009 |
| Drug Name: | ALS-L1023 |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | 141-78-6, 8014-71-9 |
| Repositioning for NAFLD: | No |
| SMILES: | O(C(=O)C)CC |
| Structure: |
|
| InChiKey: | XEKOWRVHYACXOJ-UHFFFAOYSA-N |
| Molecular Weight: | 88.106 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | PPARA / Angiogenesis |
| Therapeutic Category: | Anti-inflammatory |
| Clinical Trial Progress: | Phase 2 on-going (NCT04342793) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0271 | NCT04342793 | Phase 2 | Recruiting | No Results Available | December 4, 2019 | January 13, 2021 | Details |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01605 | 34681219 | Pharmaceuticals (Basel) | Antiangiogenic Drugs in NASH: Evidence of a Possible New Therapeutic Approach. | Details |
| A16100 | 28571771 | Food Chem Toxicol | The lemon balm extract ALS-L1023 inhibits obesity and nonalcoholic fatty liver disease in female ovariectomized mice. | Details |
| A16393 | 28420164 | Int J Mol Sci | The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease through Regulating the Visceral Adipose-Tissue Function. | Details |