Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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apoptosis14 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D032 | Betaine | Chemical drug | DB06756 | DNMTs stimulant | Improve insulin resistance | Under clinical trials | Details |
| D075 | Choline | Supplement | DB00122 | PLD2 product of; PLD1 product of | -- | Under clinical trials | Details |
| D092 | Curcumin | Chemical drug | DB11672 | PPARG; COX inhibitor | Anticancer agent; NSAID | Under clinical trials | Details |
| D105 | DHA | Chemical drug | DB03756 | PPARA ligand; PPARG ligand | Anti-inflammatory | Under clinical trials | Details |
| D123 | Emricasan | Chemical drug | DB05408 | caspase inhibitor | Anti-inflammatory | Failed in clinical trials | Details |
| D134 | Fenretinide | Chemical drug | DB05076 | RARB agonist; RARG agonist | Anti-fibrosis | Under clinical trials | Details |
| D137 | Fish oil | Biological drug | DB13961 | -- | -- | Under clinical trials | Details |
| D251 | OKT3 | Biological drug | DB00075 | CD3E antagonist | Immunosuppressant | Under clinical trials | Details |
| D383 | Vildagliptin | Chemical drug | DB04876 | DPP4 inhibitor | Antidiabetic drug | Under clinical trials | Details |
| D395 | Zinc | Chemical drug | DB01593 | PSPH; CCS; HDAC1 cofactor; HDAC4 cofactor; INS; UTRN; ASPA cofactor; TP73 cofactor; A2M; AGT; APOBR; APOE; APOL1; C3; C5; CFB; CFH; CFI; CLU; CP; CPN2; DSP; F12; F13B; FGA; GSN; HBB; HPR; JUP; SELENOP; TTR; VTN | -- | Under clinical trials | Details |
| D616 | ECH1 | Miscellany | -- | Ferroptosis inhibitor | Anti-apoptosis | Under investigation | Details |
| D617 | Glutathione S-transferase Mu 2 | Miscellany | -- | ASK1 inhibitor | Anti-apoptosis | Under investigation | Details |
| D618 | Adeno-associated virus 8 (AAV8)-TNFAIP3 injection | Miscellany | -- | ASK1 inhibitor | Anti-apoptosis | Under investigation | Details |
| D619 | Peptide fragment of CFLAR | Biological drug | -- | ASK1 inhibitor | Anti-apoptosis | Under investigation | Details |