In vitro & In vivo Models

In vitro & in vivo models of NAFLD are manually extracted from research articles.

68 records.
Model ID Category Class Type Model Description Source Reference (PMIDs)
M021 In vitro Cell culture Monoculture Hepatocyte-like cells Hepatocyte-like cells (HLCs) derived from human embryonic stem cells Human 29786565
M022 In vitro Cell culture Monoculture Human pluripotent stem cell Human pluripotent stem cell (hPSC)-derived model of hepatic steatosis Human 33409477
M023 In vitro Cell culture Co-culture Huh7/LX-2 Co-culture of the human hepatocyte cell line (HuH7) and HSC cells (LX2) Human 26187275
M024 In vitro Cell culture Co-culture Macrophages Co-cultures including macrophages Human 30824190
M025 In vitro Cell culture Co-culture hiPSC-Hep Co-cultures of human induced pluripotent stem cell-derived hepatocytes (hiPSC-Hep) Human 30254132
M026 In vitro Cell culture Collagen gel sandwich Hepatic collagen gel sandwich Extended primary culture of human hepatocytes in a collagen gel sandwich system Human 9201515
M027 In vitro Tissue culture Spheroid HepG2 spheroid Fat-loaded HepG2 spheroids Human 17211854
M028 In vivo Animal Monkey Aged rhesus monkeys Rhesus monkeys with and without metabolic syndrome (MetS) Monkey 30214501
M029 In vitro Tissue culture Spheroid PHH spheroid Primary human hepatocytes (PHH) from different donors were cultured as spheroid microtissues in physiological in vivo -like culture conditions Human 30250238
M030 In vitro Tissue culture Spheroid Hetero-cellular spheroid Comprised of primary human hepatocytes (PHH) co-cultured with crude fractions of primary human liver non-parenchymal cells (NPC) from several matched or non-matched donors Human 32295224
M031 In vitro Tissue culture Spheroid 3D PHH spheroid Co-cultured PHH-based spheroids with KC, HSC, and biliary cells Human 27143246
M032 In vitro Tissue culture Spheroid Multicellular spheroid Consisted of lipid-loaded monolayer cultures of hepatocytes (Hepa1-6) and macrophages (RAW264.7) Human 33006712
M033 In vitro Tissue culture Spheroid HepG2-HSC spheroid Depleted LPIAT1 in cultured human hepatic cells using CRISPR-Cas9 systems or siRNA Human 32253259
M034 In vitro Tissue culture Spheroid HepG2-LX-2 spheroid multilineage 3D spheroids composed by hepatocytes (HepG2) and hepatic stellate cells (LX-2) with a physiological ratio (24:1) Human 30986904
M035 In vitro Tissue culture Organoid Murine organoid Liver organoids from different degrees [defined as mild (NASH A), moderate (NASH B) and severe (NASH C)] of methionine- and choline-deficient diet-induced NASH model mice Mouse 32044522
M036 In vitro Tissue culture Organoid Human organoid Multi-cellular human liver organoids composed of hepatocyte-, stellate-, and Kupffer-like cells that exhibit transcriptomic resemblance to in vivo-derived tissues Human 31155493
M037 In vitro Tissue culture Organoid iPSC-derived cryopreservable hepatocytes Co-cultured with physiologically-relevant ratios of isogenic HSC-like and Kupffer-like cells on collagen-coated ultra-low binding plates Human 33268331
M038 In vitro Tissue culture Organoid Bipotent ductal organoid End-stage NASH patient liver explants, with normal donor livers as controls Human 33901295
M039 In vitro Tissue culture Organoid Human pluripotent stem cell-derived organoid H1 human embryonic stem cells (WA-01, passage 27-40) and induced pluripotent stem cells (GM23338) with a series of chemically defined and serum-free media to induce formation of posterior foregut cells, which were differentiated in 3 dimensions into hepatic endoderm spheroids and stepwise into hepatoblast spheroids Human 32553762
M040 In vitro Tissue culture Organoid hiPSCs organoid Hepatic organoids from human induced pluripotent stem cells (hiPSCs) using short exposure to nonengineered matrices Human 32923835