In vitro & In vivo Models

In vitro & in vivo models of NAFLD are manually extracted from research articles.

68 records.
Model ID Category Class Type Model Description Source Reference (PMIDs)
M061 In vivo Animal Genetic mouse KK-Ay/a Mice Male KK-A(y) mice and C57Bl/6 mice were fed an MCD diet for up to 8 weeks Mouse 16920398
M062 In vivo Animal Genetic mouse Phosphatase and Tensin Homolog (PTEN) Null Mice Hepatocyte-specific null mutation of Pten in mice (AlbCrePten(flox/flox) mice) Mouse 15199412
M063 In vivo Animal Genetic mouse Peroxisome Proliferator-Activated Receptor α (PPARα) Null Mice Adult mice lacking PPARalpha (PPARalpha-/-) Mouse 10377439
M064 In vivo Animal Genetic mouse Acyl-coenzyme A Oxidase (AOX) Null Mice Homozygous (ACOX -/-) mice lacked the expression of ACOX protein and accumulate very long chain fatty acids in blood. Mouse 8798738
M065 In vivo Animal Genetic mouse Methionine Adenosyl Transferase (MAT1A) Null Mice MAT1A mRNA and protein levels were absent in homozygous knockout mice Mouse 11320206
M066 In vivo Animal Minipig Göttingen Minipigs Castrated male Göttingen Minipigs were fed either chow (n = 5) or one of the three NASH diets: FFC (n = 5), CDAHFD with sucrose (CDAHFD-S; n = 4), or fructose (CDAHFD-F; n = 4) for 8 weeks. Swine 32405177
M067 In vivo Animal Minipig Ossabaw Island (Ossabaw pigs) Ossabaw pigs were fed standard chow (controls, n = 15), high-fructose diet (20% kcal from fructose and 10.5% kcal from fat) (fructose group, n = 9), atherogenic diet (20% kcal from fructose and 46% kcal from fat and 2% cholesterol and 0.7% cholate by weight) (atherogenic diet group, n = 13), and modified atherogenic diet (different source of fat and higher protein but lower choline content) (M-Ath diet group, n = 7). Swine 19434740
M068 In vivo Animal Rabbit Rabbit Feeding rabbits a diet supplemented with 0.75% cholesterol and 12% corn oil. Rabbit 20489159