Pathogenesis

Pathogenesis information of NAFLD is manually extracted from research articles.

Disease pathway of NAFLD (Kyoto Encyclopedia of Genes and Genomes)

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     PPAR
1 records.
Path ID Pathogenesis Other Terms Description Reference (PMIDs)
P06 Intrahepatic inflammation Immune dysregulation; Inflammasome activation The activation of inflammasomes in response to FFAs, oxidative stress and other pro-inflammatory metabolites seen in NAFLD with consequent production of IL-1β could have an important role in the development of NASH, by inducing suppression of peroxisome proliferator-activated receptor-α (PPAR-α), and promoting the indirect effect of TNF-α-induced cell death. 33220492; 26823198; 30482910;