Therapeutic Strategy Details
| Strategy ID: | S10 |
| Strategy: | Liver transplantation |
| Other Terms: | None |
| Related Targets: | None |
| Related Drugs: | None |
| Mechanism: | NASH-associated cirrhosis is to date among the top three indications for liver transplantation in most high-income countries, with the alarming trajectory to become the most common. Outcomes at 1, 3, and 5 years for patients undergoing a liver transplant for NASH-associated cirrhosis are substantially similar to those for other indications. |
| Reference (PMIDs): | 12000605; 24076414 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00020 | 35251901 | Australas J Ultrasound Med | Portal Venous Pulsatility Index as a predictor of fibrosis in patients with non-alcoholic fatty liver disease. | Details |
| A00058 | 35238782 | Turk J Gastroenterol | Evaluation of Magnetic Resonance Elastography and Transient Elastography for Liver Fibrosis and Steatosis Assessments in the Liver Transplant Setting. | Details |
| A00074 | 35230042 | Swiss Med Wkly | Increasing prevalence of obesity and diabetes among patients evaluated for liver transplantation in a Swiss tertiary referral center: a 10-year retrospective analysis. | Details |
| A00132 | 35212989 | Methods Mol Biol | Purification and Isolation of Hepatic Stellate Cells. | Details |
| A00143 | 35211584 | World J Clin Cases | Nonalcoholic fatty liver disease shows significant sex dimorphism. | Details |
| A00145 | 35208613 | Medicina (Kaunas) | Nash Up, Virus Down: How the Waiting List Is Changing for Liver Transplantation: A Single Center Experience from Italy. | Details |
| A00195 | 35190696 | Acta Pharmacol Sin | Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis. | Details |
| A00216 | 35181565 | Clin Gastroenterol Hepatol | UNOS Down-staging Criteria for Liver Transplantation of Hepatocellular Carcinoma: Systematic Review and Meta-Analysis of 25 Studies. | Details |
| A00233 | 35173541 | Int J Biol Sci | The role of MLKL in Hepatic Ischemia-Reperfusion Injury of Alcoholic Steatotic Livers. | Details |
| A00236 | 35172328 | J Clin Endocrinol Metab | Growth hormone and insulin-like growth factor I regulation of nonalcoholic fatty liver disease. | Details |
| A00242 | 35170434 | Saudi J Gastroenterol | Saudi association for the study of liver diseases and transplantation position statement on the hepatology workforce in Saudi Arabia. | Details |
| A00250 | 35165568 | Cureus | Efficacy of Lipid Ratios and Platelet Distribution Width for Assessment of Liver Fibrosis in Patients With Non-alcoholic Fatty Liver Disease. | Details |
| A00274 | 35157960 | J Hepatol | Hepatic lymphatic vascular system in health and disease. | Details |
| A00298 | 35146945 | Hepatol Commun | A Genetic and Metabolic Staging System for Predicting the Outcome of Nonalcoholic Fatty Liver Disease. | Details |
| A00339 | 35129295 | Liver Int | Differential fuel utilization in liver transplant recipients and its relationship with non-alcoholic fatty liver disease. | Details |
| A00371 | 35114889 | Organogenesis | Therapeutic Potential of HNF4α in End-stage Liver Disease. | Details |
| A00379 | 35110952 | World J Gastroenterol | Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link. | Details |
| A00407 | 35096933 | Front Nutr | Genetic and Life Style Risk Factors for Recurrent Non-alcoholic Fatty Liver Disease Following Liver Transplantation. | Details |
| A00440 | 35083304 | Front Cardiovasc Med | Oxidized Lipids: Common Immunogenic Drivers of Non-Alcoholic Fatty Liver Disease and Atherosclerosis. | Details |
| A00446 | 35080048 | J Gastroenterol Hepatol | Malaysian Society of Gastroenterology and Hepatology consensus statement on metabolic dysfunction-associated fatty liver disease. | Details |