Therapeutic Strategy Details
| Strategy ID: | S15 |
| Strategy: | Cell therapy |
| Other Terms: | Mesenchymal stem cells; Stem cell therapy |
| Related Targets: | None |
| Related Drugs: | None |
| Mechanism: | Mesenchymal stem cells (MSCs) have the potential for self-renewal and differentiation into multiple cell lineages, including hepatocytes. The migration and engraftation of MSCs into targeted lesions may exert clinical efficacy, such as the improvement of liver fibrosis in patients with NASH. |
| Reference (PMIDs): | 22108588; 35123561 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0665 | DB04974 | investigational | small molecule | Rimiducid | Therapeutic strategy associated | Details |
| R1501 | DB13915 | approved | biotech | Axicabtagene ciloleucel | Therapeutic strategy associated | Details |
| R1585 | DB15868 | investigational | biotech | Amniotic Epithelial Cells | Therapeutic strategy associated | Details |
| R1594 | DB16367 | approved; investigational | biotech | Autologous peripheral blood-derived CD34+ cells | Therapeutic strategy associated | Details |
| R1605 | DB16665 | approved | biotech | Idecabtagene vicleucel | Target associated | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A02478 | 34359642 | Cancers (Basel) | The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma. | Details |
| A03187 | 34095367 | Regen Ther | Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy. | Details |
| A03514 | 33974812 | Annu Rev Biomed Eng | Cell and Tissue Therapy for the Treatment of Chronic Liver Disease. | Details |
| A09354 | 31781248 | Stem Cells Int | Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice. | Details |
| A09717 | 31635053 | Cells | Magnetic-Assisted Treatment of Liver Fibrosis. | Details |
| A10449 | 31333307 | World J Gastroenterol | Hepatocellular carcinoma: Therapeutic advances in signaling, epigenetic and immune targets. | Details |
| A10548 | 31293335 | World J Gastroenterol | Immunotherapy for hepatocellular carcinoma: Current and future. | Details |
| A13330 | 30027532 | Hepatol Int | Linking the gut and liver: crosstalk between regulatory T cells and mucosa-associated invariant T cells. | Details |
| A21625 | 25173373 | Methods Mol Biol | Treatment of NASH with human mesenchymal stem cells in the immunodeficient mouse. | Details |
| A22149 | 24786317 | Exp Cell Res | Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model. | Details |
| A29367 | 34176099 | Drug Deliv Transl Res | Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies. | Details |
| A29380 | 34159305 | JHEP Rep | Novel vectors and approaches for gene therapy in liver diseases. | Details |
| A30810 | 31747961 | Stem Cell Res Ther | Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats. | Details |
| A30854 | 31667206 | Regen Ther | Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions. | Details |
| A37790 | 14652850 | Biol Blood Marrow Transplant | Adoptive immunotherapy to increase the level of donor hematopoietic chimerism after nonmyeloablative marrow transplantation for severe canine hereditary hemolytic anemia. | Details |
| A38211 | 11890207 | Crit Rev Clin Lab Sci | Mechanisms of liver injury relevant to pediatric hepatology. | Details |
| A45893 | 22167651 | Methods Mol Biol | Mesenchymal stem cell therapy on murine model of nonalcoholic steatohepatitis. | Details |
| A46694 | 16471264 | J Soc Biol | [Experimental modulation of apoptosis: physiopathological and therapeutic targets]. | Details |
| A47827 | 31281379 | Stem Cells Int | Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis. | Details |
| A48846 | 26755858 | World J Gastroenterol | Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. | Details |