Therapeutic Strategy Details
| Strategy ID: | S17 |
| Strategy: | Genetic therapy |
| Other Terms: | Genetic approaches; genetherapy; Gene therapy |
| Related Targets: | HSD17B13 inhibitor; PNPLA3-rs7 38409 (I148M) variant inhibitor; PNPLA3 expression down-regulator |
| Related Drugs: | INI-678; Momelotinib |
| Mechanism: | Particular sequences in 4 different areas of the human genome were seen at different frequencies in the fatty liver disease cases. These sequences may help predict an individual's risk of developing advanced disease. Some genes where these sequences are located may also be good targets for future drug treatments. |
| Reference (PMIDs): | 21157426; 32298765 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A04639 | 33554867 | Mol Ther | Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice. | Details |
| A06999 | 32666604 | FASEB J | Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. | Details |
| A09550 | 31696817 | Curr Gene Ther | Non-coding RNA Associated Competitive Endogenous RNA Regulatory Network: Novel Therapeutic Approach in Liver Fibrosis. | Details |
| A10449 | 31333307 | World J Gastroenterol | Hepatocellular carcinoma: Therapeutic advances in signaling, epigenetic and immune targets. | Details |
| A10594 | 31278269 | Nat Commun | Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy. | Details |
| A10707 | 31227825 | Hum Mol Genet | Recent advances in novel therapies for lipid disorders. | Details |
| A10749 | 31211621 | Am J Physiol Endocrinol Metab | Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation. | Details |
| A11672 | 30794635 | PLoS One | NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice. | Details |
| A12816 | 30271077 | World J Gastroenterol | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease. | Details |
| A13001 | 30186875 | J Diabetes Res | Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats. | Details |
| A13490 | 29951838 | Biochem Genet | Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions. | Details |
| A13512 | 29940269 | J Hepatol | Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. | Details |
| A14237 | 29511346 | Oncogene | Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer. | Details |
| A15091 | 29101357 | Sci Rep | MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1. | Details |
| A18062 | 27377869 | Clin Exp Immunol | MicroRNA-26a-interleukin (IL)-6-IL-17 axis regulates the development of non-alcoholic fatty liver disease in a murine model. | Details |
| A19174 | 29889452 | Eksp Klin Gastroenterol | HEPATOPROTECTIVE ROLE OF PLACENTA HYDROLISAT - LAENNEC IN THE TREATMENT OF PATIENTS WITH VIRAL AND PARASITIC LIVER DISEASES. | Details |
| A20202 | 26086867 | Hum Gene Ther | Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. | Details |
| A21142 | 25518481 | Eksp Klin Gastroenterol | [Possibilities of using the noninvasive methods of investigating the morphofunctional changes in the liver in patients with non alcoholic steatohepatitis and type 2 diabetes mellitus]. | Details |
| A24326 | 22997724 | Klin Med (Mosk) | [Pathogenetic therapy of metabolic syndrome at the stage of visceral lesions]. | Details |
| A26321 | 20653983 | Lipids Health Dis | Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats. | Details |