Therapeutic Strategy Details
| Strategy ID: | S08 |
| Strategy: | Lifestyle measures |
| Other Terms: | Lifestyle intervention; weight loss; diet adaptation; dietary interventions; lifestyle modifications; Exercise |
| Related Targets: | None |
| Related Drugs: | None |
| Mechanism: | Many studies exist that analyzed the effects of lifestyle and weight loss on NAFLD and the risk of subsequent NASH, including MRI spectroscopy studies. Results in overweight patients with biopsy-proven NAFLD could confirm initial findings, also offering the opportunity to assess important changes in inflammation, lobular changes, and fibrosis. Improvements in lifestyle can have immediate and sometimes significant effects on the liver in NAFLD patients, and may contribute to the high rate of ‘placebo response’ observed in NASH trials. |
| Reference (PMIDs): | 2210247; 20664019; 28862886 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00001 | 35259705 | Diabetes Metab Syndr | Role of diabetologists in the management of nonalcoholic fatty liver disease: Primary prevention and screening/management of fibrosis and cirrhosis. | Details |
| A00011 | 35255600 | Endocrinol Metab (Seoul) | State-of-the-Art Overview of the Pharmacological Treatment of Non-Alcoholic Steatohepatitis. | Details |
| A00021 | 35251583 | J Healthc Eng | Preliminary Study on Risk Factors for Morbidity of Nonalcoholic Fatty Liver Disease in High-Income Male Population. | Details |
| A00050 | 35243111 | Transl Gastroenterol Hepatol | Palm tocotrienol rich fraction with palm kernel oil supplementation prevents development of liver steatosis in high fat diet ICR mice. | Details |
| A00057 | 35238939 | J Clin Endocrinol Metab | Long or Irregular Menstrual Cycles and Risk of Prevalent and Incident Nonalcoholic Fatty Liver Disease. | Details |
| A00077 | 35229329 | Hepatology | Risk Factors for Hepatocellular Cancer in Contemporary Cohorts of Patients with Cirrhosis. | Details |
| A00086 | 35225189 | Br J Nutr | Organ meat consumption and risk of nonalcoholic fatty liver disease: the TCLSIH study. | Details |
| A00097 | 35220673 | Liver Int | Knowledge of liver fibrosis stage among adults with NAFLD/NASH improves adherence to lifestyle changes. | Details |
| A00102 | 35218767 | Life Sci | Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation. | Details |
| A00154 | 35207209 | J Clin Med | Nonalcoholic Fatty Liver Disease Is a Precursor of New-Onset Metabolic Syndrome in Metabolically Healthy Young Adults. | Details |
| A00168 | 35203457 | Biomedicines | Hypercoagulability in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD): Causes and Consequences. | Details |
| A00226 | 35176096 | PLoS One | Lifestyle changes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis. | Details |
| A00276 | 35154609 | Gastroenterol Hepatol Bed Bench | Predictors of metabolic-associated fatty liver disease (MAFLD) in adults: a population-based study in Northeastern Iran. | Details |
| A00322 | 35136128 | Sci Rep | Favorable association between Mediterranean diet (MeD) and DASH with NAFLD among Iranian adults of the Amol Cohort Study (AmolCS). | Details |
| A00334 | 35131122 | Clin Investig Arterioscler | Dietary patterns in non-alcoholic fatty liver disease (NAFLD): Stay on the straight and narrow path! | Details |
| A00344 | 35126846 | World J Hepatol | Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence. | Details |
| A00364 | 35118444 | touchREV Endocrinol | Potential Role of Dexamphetamine in the Treatment of Non-alcoholic Fatty Liver Disease: Hopes and Pitfalls. | Details |
| A00385 | 35107763 | Curr Atheroscler Rep | Childhood Hypertriglyceridemia: Is It Time for a New Approach? | Details |
| A00446 | 35080048 | J Gastroenterol Hepatol | Malaysian Society of Gastroenterology and Hepatology consensus statement on metabolic dysfunction-associated fatty liver disease. | Details |
| A00453 | 35076162 | Hepatol Commun | Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community-Based Sample of Mexican-Origin Adults. | Details |