Therapeutic Strategy Details
| Strategy ID: | S09 |
| Strategy: | Bariatric surgery |
| Other Terms: | Metabolic surgery |
| Related Targets: | None |
| Related Drugs: | None |
| Mechanism: | Metabolic surgery reduces ectopic fat, hepatic fat in particular, contributing to a marked improvement of NAFLD/NASH manifestations. |
| Reference (PMIDs): | 15605305; 31754142; 22939560 |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00032 | 35250014 | Ultrasound Q | Clinical Feasibility of Shear Wave Dispersion Slope for Noninvasive Diagnosis of Nonalcoholic Steatohepatitis in Patients With Morbid Obesity: Preliminary Results Using US Shear Wave Elastography. | Details |
| A00073 | 35230526 | Langenbecks Arch Surg | Is there a role for preoperative liver reducing diet in hepatectomy? A systematic review. | Details |
| A00221 | 35178496 | APL Bioeng | Development of resveratrol with thiolated alginate as a supplement to prevent nonalcoholic fatty liver disease (NAFLD). | Details |
| A00224 | 35178085 | Gastroenterol Res Pract | The Risk Factors of Nonalcoholic Fatty Liver Disease in Morbidly Obese Patients Undergoing Bariatric Surgery in Iran. | Details |
| A00267 | 35160204 | J Clin Med | Liraglutide + PYY3-36 Combination Therapy Mimics Effects of Roux-en-Y Bypass on Early NAFLD Whilst Lacking-Behind in Metabolic Improvements. | Details |
| A00360 | 35120767 | Med Clin (Barc) | Bariatric surgery and non-alcoholic fatty liver disease. | Details |
| A00387 | 35107488 | Arq Bras Cir Dig | OBESITY AND SEVERE STEATOSIS: THE IMPORTANCE OF BIOCHEMICAL EXAMS AND SCORES. | Details |
| A00446 | 35080048 | J Gastroenterol Hepatol | Malaysian Society of Gastroenterology and Hepatology consensus statement on metabolic dysfunction-associated fatty liver disease. | Details |
| A00526 | 35053205 | Biomolecules | Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives. | Details |
| A00601 | 35034646 | Lipids Health Dis | The relationship between Lipocalin-2 level and hepatic steatosis in obese patients with NAFLD after bariatric surgery. | Details |
| A00616 | 35027111 | J Am Coll Cardiol | Risk of Heart Failure in Patients With Nonalcoholic Fatty Liver Disease: JACC Review Topic of the Week. | Details |
| A00643 | 35016856 | Obes Res Clin Pract | High-priority liver transplantation and simultaneous sleeve gastrectomy in MELD 32 end-stage liver disease: a case report with long-term follow-up. | Details |
| A00651 | 35014161 | Diabetes Obes Metab | The metabolic triad of non-alcoholic fatty liver disease, visceral adiposity and type 2 diabetes: Implications for treatment. | Details |
| A00694 | 35000203 | Hepatology | Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD. | Details |
| A00723 | 34988895 | Obes Surg | Prevalence of Elevated Liver Stiffness Among Potential Candidates for Bariatric Surgery in the United States. | Details |
| A00747 | 34981313 | Dig Dis Sci | Bariatric Surgery in NAFLD. | Details |
| A00750 | 34980714 | J Nutr Sci Vitaminol (Tokyo) | Fasting, Nutrition and Weight Loss: An Approach to Refine Non-Alcoholic Fatty Liver Disease. | Details |
| A00771 | 34973842 | Transplant Proc | Bariatric Surgery and Solid-Organ Transplantation. | Details |
| A00857 | 34945016 | J Clin Med | Non-Alcoholic Fatty Liver Disease (NAFLD) and Bariatric/Metabolic Surgery as Its Treatment Option: A Review. | Details |
| A00934 | 34924365 | J Obes Metab Syndr | Severe Obesity in Children and Adolescents: Metabolic Effects, Assessment, and Treatment. | Details |