Therapeutic Target Details
| Target ID: | T12 |
| Target Name: | Caspase-7 |
| Synonyms: | Apoptotic protease Mch-3; CASP-7; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; MCH3; CASP7 |
| GENE: | CASP7 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | P55210 |
| Entry Name: | CASP7_HUMAN |
| Related Drugs: | Emricasan |
| Mechanism: | Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. |
| Reference (PMIDs): | 29991872 |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000002 | CHEMBL100114 | Small molecule | -- | 444.48 | C23H28N2O7 | NEUTRAL | Details |
| B000005 | CHEMBL100405 | Small molecule | -- | 414.46 | C22H26N2O6 | NEUTRAL | Details |
| B000006 | CHEMBL100409 | Small molecule | -- | 483.35 | C22H24Cl2N2O6 | NEUTRAL | Details |
| B000009 | CHEMBL100559 | Small molecule | -- | 547.51 | C22H24F3N3O8S | ACID | Details |
| B000010 | CHEMBL100578 | Small molecule | -- | 415.45 | C21H25N3O6 | NEUTRAL | Details |
| B000011 | CHEMBL100588 | Small molecule | -- | 493.51 | C23H31N3O9 | ACID | Details |
| B000012 | CHEMBL100591 | Small molecule | -- | 547.51 | C22H24F3N3O8S | ACID | Details |
| B000015 | CHEMBL100643 | Small molecule | -- | 486.52 | C25H30N2O8 | ACID | Details |
| B000016 | CHEMBL100741 | Small molecule | -- | 364.4 | C18H24N2O6 | NEUTRAL | Details |
| B000017 | CHEMBL100769 | Small molecule | -- | 426.51 | C24H30N2O5 | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A24830 | 22455888 | Zhonghua Bing Li Xue Za Zhi | [Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet]. | Details |
| A46231 | 20156580 | Int J Biochem Cell Biol | Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. | Details |
| A46259 | 19949375 | Lab Invest | Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet. | Details |