Therapeutic Target Details
| Target ID: | T13 |
| Target Name: | Apoptosis Signal-regulating Kinase 1 |
| Synonyms: | ASK1; ASK-1 |
| GENE: | ASK1 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | Q99683 |
| Entry Name: | M3K5_HUMAN |
| Related Drugs: | Selonsertib |
| Mechanism: | In human livers of lean and obese subjects, ASK1 expression correlated negatively with liver fat content and NASH scores, but positively with markers for autophagy. Taken together, ASK1 may be a novel therapeutic target to tackle NAFLD and liver fibrosis. Hepatocyte GSTM2 is an endogenous suppressor that protects against NASH progression by blocking ASK1 N-terminal dimerization and phosphorylation. Activating GSTM2 holds promise as a therapeutic strategy for NASH. |
| Reference (PMIDs): | 31595673; 34656650 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | Details |
| A01680 | 34656650 | J Hepatol | Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. | Details |
| A01846 | 34591986 | Hepatology | OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways. | Details |
| A03067 | 34144391 | Redox Biol | Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. | Details |
| A04207 | 33713358 | Hepatology | TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. | Details |
| A07359 | 32526787 | Semin Liver Dis | Nonalcoholic Steatohepatitis Promoting Kinases. | Details |
| A07397 | 32514497 | JHEP Rep | Combined alcoholic and non-alcoholic steatohepatitis. | Details |
| A07905 | 32316235 | J Clin Med | The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis. | Details |
| A07964 | 32297339 | Hepatology | Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation. | Details |
| A08342 | 32147362 | J Hepatol | Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials. | Details |
| A09534 | 31705800 | Hepatology | Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets. | Details |
| A09830 | 31595673 | EMBO Mol Med | Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis. | Details |
| A09967 | 31541591 | J Pineal Res | Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner. | Details |
| A11609 | 30820969 | Hepatology | Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal-Regulating Kinase 1 Pathways. | Details |
| A11866 | 30703849 | Hepatology | F-box/WD Repeat-Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal-Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice. | Details |
| A12898 | 30235807 | Diseases | Emerging Therapeutic Targets and Experimental Drugs for the Treatment of NAFLD. | Details |
| A12967 | 30205811 | BMC Med | An exploratory study examining how nano-liquid chromatography-mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease. | Details |
| A13254 | 30063256 | Hepatology | Dual-Specificity Phosphatase 9 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through ASK1 Suppression. | Details |
| A13843 | 29729191 | Hepatology | Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal-Regulating Kinase 1. | Details |
| A14796 | 29227477 | Nat Med | The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. | Details |