Therapeutic Target Details
| Target ID: | T14 |
| Target Name: | Mitogen-activated protein kinase kinase kinase 5 |
| Synonyms: | MAP3K5; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5 |
| GENE: | MAP3K5 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | Q99683 |
| Entry Name: | M3K5_HUMAN |
| Related Drugs: | Selonsertib |
| Mechanism: | CASP8 and FADD-like apoptosis regulator (CFLAR) as a key suppressor of steatohepatitis and indicate that the development of CFLAR-peptide-mimicking drugs and the screening of small-molecular inhibitors that specifically block ASK1 dimerization are new and feasible approaches for NASH treatment. |
| Reference (PMIDs): | 28218919 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000001 | CHEMBL10 | Small molecule | SB-203580 | 377.44 | C21H16FN3OS | NEUTRAL | Details |
| B000008 | CHEMBL100473 | Small molecule | U-0126 | 380.5 | C18H16N6S2 | NEUTRAL | Details |
| B000035 | CHEMBL101253 | Small molecule | VATALANIB | 346.82 | C20H15ClN4 | NEUTRAL | Details |
| B000053 | CHEMBL101683 | Small molecule | -- | 337.81 | C19H16ClN3O | NEUTRAL | Details |
| B000058 | CHEMBL101797 | Small molecule | -- | 210.24 | C13H10N2O | NEUTRAL | Details |
| B000073 | CHEMBL102346 | Small molecule | -- | 485.54 | C27H27N5O4 | NEUTRAL | Details |
| B000090 | CHEMBL103552 | Small molecule | LAVENDUSTIN A | 381.38 | C21H19NO6 | ACID | Details |
| B000095 | CHEMBL103667 | Small molecule | DORAMAPIMOD | 527.67 | C31H37N5O3 | NEUTRAL | Details |
| B000108 | CHEMBL104264 | Small molecule | -- | 446.37 | C20H20BrN3O2S | NEUTRAL | Details |
| B000109 | CHEMBL104279 | Small molecule | -- | 353.4 | C18H15N3O3S | NEUTRAL | Details |