Therapeutic Target Details
| Target ID: | T17 |
| Target Name: | Farnesoid X-activated receptor |
| Synonyms: | FXR; Bile acid receptor |
| GENE: | NR1H4 |
| Action: | agonist |
| Class: | Nuclear hormone receptor |
| UniProtKB ID: | Q96RI1 |
| Entry Name: | NR1H4_HUMAN |
| Related Drugs: | Obeticholic Acid; Tropifexor; Ursodeoxycholic acid |
| Mechanism: | Farnesoid X receptor (FXR), a nuclear receptor for bile acids, is widely expressed in the intestine, liver and kidneys, and is responsible for the homeostasis of cholesterol metabolism. |
| Reference (PMIDs): | 32552182; 28774887 |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000007 | CHEMBL10041 | Small molecule | AFIMOXIFENE | 387.52 | C26H29NO2 | BASE | Details |
| B000038 | CHEMBL101327 | Small molecule | -- | 545.92 | C28H20ClF4NO4 | ACID | Details |
| B000041 | CHEMBL101381 | Small molecule | -- | 587.3 | C28H22BrCl2NO4 | ACID | Details |
| B000048 | CHEMBL101547 | Small molecule | -- | 522.43 | C29H25Cl2NO4 | ACID | Details |
| B000083 | CHEMBL103 | Small molecule | PROGESTERONE | 314.47 | C21H30O2 | NEUTRAL | Details |
| B000089 | CHEMBL103394 | Small molecule | -- | 522.43 | C29H25Cl2NO4 | ACID | Details |
| B000101 | CHEMBL104 | Small molecule | CLOTRIMAZOLE | 344.85 | C22H17ClN2 | NEUTRAL | Details |
| B000104 | CHEMBL1042 | Small molecule | CHOLECALCIFEROL | 384.65 | C27H44O | NEUTRAL | Details |
| B000153 | CHEMBL105712 | Small molecule | PHENACYL CHLORIDE | 154.6 | C8H7ClO | NEUTRAL | Details |
| B000189 | CHEMBL107 | Small molecule | COLCHICINE | 399.44 | C22H25NO6 | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00713 | 34992541 | Front Pharmacol | Diammonium Glycyrrhizinate Ameliorates Obesity Through Modulation of Gut Microbiota-Conjugated BAs-FXR Signaling. | Details |
| A10256 | 31409057 | Cells | iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation. | Details |