Therapeutic Target Details
| Target ID: | T18 |
| Target Name: | Acetyl-CoA carboxylase 1 |
| Synonyms: | ACC; ACC1; ACCA; ACC-alpha; ACAC; ACACA |
| GENE: | ACACA |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | Q13085 |
| Entry Name: | ACACA_HUMAN |
| Related Drugs: | Firsocostat |
| Mechanism: | Acetyl-CoA carboxylases (ACCs) catalyse the committed step in DNL through the conversion of acetyl-CoA to malonyl-CoA. Furthermore, the product of this reaction, malonyl-CoA, is a signalling molecule that suppresses fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1. Thus, ACC inhibition could reduce hepatic lipid accumulation by suppressing DNL and stimulating fatty acid oxidation. ACC inhibitors improve hepatic steatosis and insulin sensitivity but increase plasma concentrations of triglyceride in mice, rats and humans. |
| Reference (PMIDs): | 28768177 |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000230 | CHEMBL1076223 | Small molecule | -- | 607.8 | C37H45N5O3 | NEUTRAL | Details |
| B085441 | CHEMBL1615283 | Small molecule | -- | 502.66 | C30H38N4O3 | BASE | Details |
| B085492 | CHEMBL1629723 | Small molecule | -- | 358.44 | C20H26N2O4 | NEUTRAL | Details |
| B085604 | CHEMBL1630515 | Small molecule | -- | 389.54 | C23H35NO4 | NEUTRAL | Details |
| B085605 | CHEMBL1630516 | Small molecule | -- | 344.44 | C18H20N2O3S | NEUTRAL | Details |
| B085606 | CHEMBL1630517 | Small molecule | -- | 397.52 | C24H31NO4 | NEUTRAL | Details |
| B085607 | CHEMBL1630518 | Small molecule | -- | 361.48 | C21H31NO4 | NEUTRAL | Details |
| B085608 | CHEMBL1630519 | Small molecule | -- | 397.52 | C24H31NO4 | NEUTRAL | Details |
| B085609 | CHEMBL1630520 | Small molecule | -- | 361.48 | C21H31NO4 | NEUTRAL | Details |
| B085610 | CHEMBL1630521 | Small molecule | -- | 385.46 | C22H27NO5 | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00261 | 35162967 | Int J Mol Sci | Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis. | Details |
| A00748 | 34981123 | Biosci Rep | Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture. | Details |
| A00982 | 34910548 | Sci Transl Med | A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. | Details |
| A00983 | 34910546 | Sci Transl Med | Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis. | Details |
| A01997 | 34535562 | J Pharmacol Exp Ther | Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model. | Details |
| A03197 | 34093169 | Front Pharmacol | Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway. | Details |
| A03474 | 33990765 | Acta Pharmacol Sin | Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. | Details |
| A03693 | 33900847 | Am J Physiol Endocrinol Metab | High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling. | Details |
| A05426 | 33260679 | Nutrients | The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice. | Details |
| A07015 | 32657010 | Obesity (Silver Spring) | Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver. | Details |
| A07142 | 32604760 | Nutrients | Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. | Details |
| A08330 | 32150756 | Hepatology | N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. | Details |
| A08764 | 31993306 | Acta Pharm Sin B | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. | Details |
| A08772 | 31990961 | PLoS One | Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis. | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | Details |
| A09554 | 31695954 | Food Sci Biotechnol | Dansameum regulates hepatic lipogenesis and inflammation in vitro and in vivo. | Details |
| A09807 | 31602953 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Calculus Bovis Sativus in inhibiting hepatocyte lipid deposition based on serum pharmacology]. | Details |
| A09941 | 31551937 | Front Endocrinol (Lausanne) | Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats. | Details |
| A10099 | 31484323 | Nutrients | Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress. | Details |
| A10174 | 31454158 | Mol Nutr Food Res | Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes. | Details |