Therapeutic Target Details
| Target ID: | T22 |
| Target Name: | Stearoyl-CoA desaturase |
| Synonyms: | SCD FADS5; SCD1; SCDOS; SCD |
| GENE: | SCD |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | O00767 |
| Entry Name: | SCD_HUMAN |
| Related Drugs: | Aramchol |
| Mechanism: | Stearoyl-CoA desaturase 1 (SCD1) is a fatty acid desaturase, highly expressed in lipogenic tissues, such as adipose and liver, that converts saturated fatty acids, such as palmitate and stearate, to monounsaturated fatty acids. |
| Reference (PMIDs): | 29089222 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000264 | CHEMBL1076688 | Small molecule | -- | 387.45 | C16H16F3N3OS2 | NEUTRAL | Details |
| B000265 | CHEMBL1076698 | Small molecule | -- | 371.38 | C16H16F3N3O2S | NEUTRAL | Details |
| B000417 | CHEMBL1080558 | Small molecule | -- | 420.44 | C15H15F3N4O3S2 | NEUTRAL | Details |
| B000418 | CHEMBL1080559 | Small molecule | -- | 370.4 | C16H17F3N4OS | NEUTRAL | Details |
| B000428 | CHEMBL1080909 | Small molecule | -- | 371.38 | C16H16F3N3O2S | NEUTRAL | Details |
| B000431 | CHEMBL1080940 | Small molecule | -- | 356.3 | C15H15F3N4O3 | NEUTRAL | Details |
| B000432 | CHEMBL1080941 | Small molecule | -- | 355.32 | C15H16F3N5O2 | NEUTRAL | Details |
| B000442 | CHEMBL1081111 | Small molecule | -- | 355.32 | C16H16F3N3O3 | NEUTRAL | Details |
| B000443 | CHEMBL1081112 | Small molecule | -- | 407.44 | C15H16F3N3O3S2 | NEUTRAL | Details |
| B000444 | CHEMBL1081113 | Small molecule | -- | 411.45 | C19H20F3N3O2S | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00174 | 35198905 | iScience | Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity. | Details |
| A00344 | 35126846 | World J Hepatol | Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence. | Details |
| A00356 | 35122619 | J Physiol Biochem | Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis. | Details |
| A00538 | 35052685 | Biomedicines | Fatty Acid Synthase Inhibitor Platensimycin Intervenes the Development of Nonalcoholic Fatty Liver Disease in a Mouse Model. | Details |
| A00658 | 35013040 | J Oleo Sci | Pink Lotus Essential Oil and Alleviates on Free Fatty Acid Induced Steatosis in HepG2 Cells via PI3K/Akt and NF-κB Pathways. | Details |
| A01411 | 34757160 | Toxicology | The combined impact of decabromodiphenyl ether and high fat exposure on non-alcoholic fatty liver disease in vivo and in vitro. | Details |
| A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | Details |
| A01775 | 34621326 | Evid Based Complement Alternat Med | A Novel Identified Peptide Hormone "Metabolitin" Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway. | Details |
| A01778 | 34621052 | Nat Med | Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial. | Details |
| A02244 | 34447968 | J Anim Sci Technol | Effect of ciglitazone on adipogenic transdifferentiation of bovine skeletal muscle satellite cells. | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | Details |
| A02309 | 34426119 | Int Immunopharmacol | Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/ SCD1 signaling pathway and modulating gut microbiota. | Details |
| A02993 | 34171462 | Biochim Biophys Acta Gene Regul Mech | Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding. | Details |
| A03200 | 34092291 | Chin J Nat Med | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α. | Details |
| A03245 | 34073834 | Int J Mol Sci | P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice. | Details |
| A03394 | 34017254 | Front Pharmacol | Geniposide and Chlorogenic Acid Combination Improves Non-Alcoholic Fatty Liver Disease Involving the Potent Suppression of Elevated Hepatic SCD-1. | Details |
| A04366 | 33647280 | Gastroenterology | Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. | Details |
| A04546 | 33583577 | Clin Ther | Therapy for Nonalcoholic Fatty Liver Disease: Current Options and Future Directions. | Details |
| A04870 | 33474802 | Pharmacol Res Perspect | Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice. | Details |
| A04984 | 33425805 | Can J Gastroenterol Hepatol | Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. | Details |