Therapeutic Target Details
| Target ID: | T28 |
| Target Name: | Fibroblast growth factor 21 |
| Synonyms: | FGF21; FGF-21 |
| GENE: | FGF21 |
| Action: | analogue |
| Class: | Secreted |
| UniProtKB ID: | Q9NSA1 |
| Entry Name: | FGF21_HUMAN |
| Related Drugs: | Pegbelfermin |
| Mechanism: | FGF21 is a key regulator of whole-body and individual organ metabolism. It activates a cell membrane co-receptor complex of β-klotho and one of its cognate FGF receptors (FGFRs), FGFR1c, FGFR2c or FGFR3c. FGF21 and its analogs improve metabolic status in preclinical models of obesity, diabetes and NASH, suggesting promise as a therapeutic for NASH. FGF-21 plays a central role in regulating energy metabolism. |
| Reference (PMIDs): | 33381084; 32764725; 26567701 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
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| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00278 | 35154523 | Arch Med Sci | Fibroblast growth factor 21 levels and liver inflammatory biomarkers in obese subjects after weight loss. | Details |
| A00386 | 35107741 | Mol Biol Rep | Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/Fgf21 signaling. | Details |
| A00467 | 35070009 | World J Hepatol | Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis. | Details |
| A00539 | 35052640 | Antioxidants (Basel) | Phytochemicals from the Cocoa Shell Modulate Mitochondrial Function, Lipid and Glucose Metabolism in Hepatocytes via Activation of FGF21/ERK, AKT, and mTOR Pathways. | Details |
| A00559 | 35046901 | Front Endocrinol (Lausanne) | The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model. | Details |
| A00597 | 35035378 | Front Endocrinol (Lausanne) | Bifidobacterium adolescentis Alleviates Liver Steatosis and Steatohepatitis by Increasing Fibroblast Growth Factor 21 Sensitivity. | Details |
| A00623 | 35024308 | Acta Pharm Sin B | Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver. | Details |
| A00650 | 35014168 | Basic Clin Pharmacol Toxicol | Efficacy of fibroblast growth factor 21 in non-alcoholic fatty liver disease in guinea pigs. | Details |
| A00760 | 34977519 | JHEP Rep | Pegbelfermin selectively reduces secondary bile acid concentrations in patients with non-alcoholic steatohepatitis. | Details |
| A00818 | 34957498 | Diabetes | Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice. | Details |
| A00872 | 34943946 | Cells | Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese Ay Mice. | Details |
| A00963 | 34917917 | Metabol Open | Emerging roles for stress kinase p38 and stress hormone fibroblast growth factor 21 in NAFLD development. | Details |
| A01114 | 34866842 | J Clin Exp Hepatol | Adipocytokines as Risk Factors for Development of Nonalcoholic Fatty Liver Disease in Children. | Details |
| A01256 | 34813496 | Physiol Int | Effect of vanillic acid and exercise training on fatty liver and insulin resistance in rats: Possible role of fibroblast growth factor 21 and autophagy. | Details |
| A01374 | 34769488 | Int J Mol Sci | The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases. | Details |
| A01537 | 34706542 | J Agric Food Chem | Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways. | Details |
| A01635 | 34675003 | Diabetes | Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice. | Details |
| A01668 | 34660809 | J Diabetes Res | Liraglutide Decreases Liver Fat Content and Serum Fibroblast Growth Factor 21 Levels in Newly Diagnosed Overweight Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Disease. | Details |
| A01685 | 34654875 | Acta Pharmacol Sin | Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway. | Details |
| A02242 | 34448598 | Metab Syndr Relat Disord | Non-Alcoholic Steatohepatitis Severity Associates with FGF21 Level and Kidney Glucose Uptake. | Details |