Therapeutic Target Details
| Target ID: | T30 |
| Target Name: | Lysyl oxidase homolog 2 |
| Synonyms: | LOXL2; LOXL-2 |
| GENE: | LOXL2 |
| Action: | antibody |
| Class: | Enzyme |
| UniProtKB ID: | Q9Y4K0 |
| Entry Name: | LOXL2_HUMAN |
| Related Drugs: | Simtuzumab |
| Mechanism: | The mechanism entails a cross-talk between enhanced lipotoxicity in insulin resistant HEPs and Loxl2 production by HSCs, which was confirmed in patients with diabetes, thereby facilitating extracellular matrix (ECM) stabilization. |
| Reference (PMIDs): | 28468951 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B001557 | CHEMBL1188378 | Small molecule | -- | 108.14 | C6H8N2 | BASE | Details |
| B001779 | CHEMBL120563 | Small molecule | THIRAM | 240.44 | C6H12N2S4 | None | Details |
| B002161 | CHEMBL1235374 | Small molecule | -- | 152.15 | C7H8N2O2 | BASE | Details |
| B002193 | CHEMBL12392 | Small molecule | -- | 125.15 | C7H8FN | BASE | Details |
| B017697 | CHEMBL1356238 | Small molecule | PYRITHIONE | 127.17 | C5H5NOS | NEUTRAL | Details |
| B051693 | CHEMBL148476 | Small molecule | -- | 122.17 | C7H10N2 | BASE | Details |
| B053041 | CHEMBL148986 | Small molecule | -- | 165.19 | C9H11NO2 | BASE | Details |
| B085451 | CHEMBL1618272 | Small molecule | -- | 70.09 | C3H6N2 | NEUTRAL | Details |
| B085473 | CHEMBL1624419 | Small molecule | -- | 204.3 | C11H12N2S | BASE | Details |
| B095527 | CHEMBL1770734 | Small molecule | -- | 164.23 | C8H8N2S | NEUTRAL | Details |
| Article ID | PMID | Source | Title |
|---|