Therapeutic Target Details
| Target ID: | T33 |
| Target Name: | Mitochondrial pyruvate carrier 1 |
| Synonyms: | MPC1 |
| GENE: | MPC1 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | Q9Y5U8 |
| Entry Name: | MPC1_HUMAN |
| Related Drugs: | MSDC-0602K |
| Mechanism: | In the past decade, the mitochondrial pyruvate carrier (MPC) was identified as a heterodimeric complex of two proteins, MPC1 and MPC2, which functions to transport pyruvate from the cytosol across the inner mitochondrial membrane. This is a required step in the conversion of carbohydrate to fatty acids via DNL. |
| Reference (PMIDs): | 22628558 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
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| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
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| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species |
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| Article ID | PMID | Source | Title |
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