Therapeutic Target Details
| Target ID: | T34 |
| Target Name: | Mitochondrial pyruvate carrier 2 |
| Synonyms: | MPC2 |
| GENE: | MPC2 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | O95563 |
| Entry Name: | MPC2_HUMAN |
| Related Drugs: | MSDC-0602K |
| Mechanism: | In the past decade, the mitochondrial pyruvate carrier (MPC) was identified as a heterodimeric complex of two proteins, MPC1 and MPC2, which functions to transport pyruvate from the cytosol across the inner mitochondrial membrane. This is a required step in the conversion of carbohydrate to fatty acids via DNL. |
| Reference (PMIDs): | 22628558 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B046703 | CHEMBL146624 | Small molecule | MITOGLITAZONE | 370.43 | C19H18N2O4S | NEUTRAL | Details |
| B137683 | CHEMBL4291468 | Small molecule | -- | 371.41 | C19H17NO5S | NEUTRAL | Details |