Therapeutic Target Details
| Target ID: | T35 |
| Target Name: | Platelet glycoprotein Ib alpha |
| Synonyms: | Platelet GPIbα; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha |
| GENE: | GP1BA |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | P07359 |
| Entry Name: | GP1BA_HUMAN |
| Related Drugs: | aspirin/clopidogrel; ticagrelor |
| Mechanism: | Platelet-derived GPIbα proved critical for development of NASH and subsequent HCC, independent of its reported cognate ligands vWF, P-selectin or Mac-1, offering a potential target against NASH. |
| Reference (PMIDs): | 30936549 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0385 | DB01050 | approved | small molecule | Ibuprofen | Target associated | Details |
| R0734 | DB05202 | investigational | biotech | Egaptivon pegol | Target associated | Details |
| R0781 | DB05391 | investigational | small molecule | liposomal prostaglandin E1 | Target associated | Details |
| R1244 | DB09213 | approved; investigational | small molecule | Dexibuprofen | Therapeutic strategy associated | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species |
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| Article ID | PMID | Source | Title |
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