Therapeutic Target Details
| Target ID: | T36 |
| Target Name: | Caspase-6 |
| Synonyms: | Caspase-6; CASP-6; CSP-6 |
| GENE: | CASP6 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | P55212 |
| Entry Name: | CASP6_HUMAN |
| Related Drugs: | None |
| Mechanism: | Active caspase-6 cleaved Bid to induce cytochrome c release, generating a feedforward loop that leads to hepatocyte death. Thus, the AMPK-caspase-6 axis regulates liver damage in NASH, implicating AMPK and caspase-6 as therapeutic targets. |
| Reference (PMIDs): | 32029622 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000002 | CHEMBL100114 | Small molecule | -- | 444.48 | C23H28N2O7 | NEUTRAL | Details |
| B000005 | CHEMBL100405 | Small molecule | -- | 414.46 | C22H26N2O6 | NEUTRAL | Details |
| B000006 | CHEMBL100409 | Small molecule | -- | 483.35 | C22H24Cl2N2O6 | NEUTRAL | Details |
| B000009 | CHEMBL100559 | Small molecule | -- | 547.51 | C22H24F3N3O8S | ACID | Details |
| B000010 | CHEMBL100578 | Small molecule | -- | 415.45 | C21H25N3O6 | NEUTRAL | Details |
| B000012 | CHEMBL100591 | Small molecule | -- | 547.51 | C22H24F3N3O8S | ACID | Details |
| B000015 | CHEMBL100643 | Small molecule | -- | 486.52 | C25H30N2O8 | ACID | Details |
| B000016 | CHEMBL100741 | Small molecule | -- | 364.4 | C18H24N2O6 | NEUTRAL | Details |
| B000017 | CHEMBL100769 | Small molecule | -- | 426.51 | C24H30N2O5 | NEUTRAL | Details |
| B000018 | CHEMBL100788 | Small molecule | -- | 470.52 | C25H30N2O7 | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A05580 | 33200549 | Basic Clin Pharmacol Toxicol | Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition. | Details |
| A08659 | 32029622 | Science | An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. | Details |