Therapeutic Target Details
| Target ID: | T38 |
| Target Name: | Caspase-4 |
| Synonyms: | Caspase-4; CASP-4; Caspase-11; CASP-11 |
| GENE: | Casp4 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | P49662 |
| Entry Name: | CASP4_HUMAN |
| Related Drugs: | None |
| Mechanism: | Upregulated caspase-11 was detected in liver of mice with NASH. MCD-treated caspase-11-deficient mice had significantly decreased liver injury, fibrosis, and inflammation. The activation of gasdermin D and interleukin-1β was inhibited in caspase-11-deficient mice after MCD treatment. Overexpression of caspase-11 promoted steatohepatitis. Caspase-11-mediated hepatocytic pyroptosis promotes the progression of NASH. |
| Reference (PMIDs): | 33894425 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B002217 | CHEMBL1241348 | Small molecule | FALDAPREVIR | 869.84 | C40H49BrN6O9S | ACID | Details |
| B032585 | CHEMBL1412861 | Small molecule | -- | 610.85 | C37H50N6O2 | NEUTRAL | Details |
| B046263 | CHEMBL146453 | Small molecule | -- | 627.12 | C25H23ClN2O9S3 | ACID | Details |
| B049425 | CHEMBL147642 | Small molecule | -- | 456.45 | C17H16N2O9S2 | ACID | Details |
| B049795 | CHEMBL147775 | Small molecule | -- | 608.05 | C25H22ClN3O9S2 | ACID | Details |
| B050847 | CHEMBL148162 | Small molecule | -- | 641.15 | C26H25ClN2O9S3 | ACID | Details |
| B053903 | CHEMBL149307 | Small molecule | -- | 623.07 | C25H23ClN4O9S2 | ACID | Details |
| B095947 | CHEMBL179503 | Small molecule | -- | 598.15 | C27H44ClN7O6 | ACID | Details |
| B105567 | CHEMBL1907830 | Small molecule | -- | 385.45 | C19H19N3O4S | NEUTRAL | Details |
| B109189 | CHEMBL207102 | Small molecule | -- | 576.99 | C29H25ClN4O7 | NEUTRAL | Details |