Therapeutic Target Details
| Target ID: | T40 |
| Target Name: | N-formyl peptide receptor 2 |
| Synonyms: | Formyl peptide receptor; FMLP-related receptor I, FMLP-R-I; Formyl peptide receptor-like 1; HM63; Lipoxin A4 receptor, LXA4 receptor; RFP |
| GENE: | FPR2 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | P25090 |
| Entry Name: | FPR2_HUMAN |
| Related Drugs: | None |
| Mechanism: | FPR2 has anti-inflammatory roles in the liver and that its sex-specific expression is closely related to sex disparities in NAFLD/NASH development. Higher expression of FPR2 in female mice than in male mice makes females more resistant to NAFLD development and progression, and severe injury in FPR2-depleted female mice supports the protective effect of FPR2 in the livers of female mice. Estrogen directly regulates FPR2 expression, which is related to estrogen-mediated protection against NAFLD. |
| Reference (PMIDs): | 35102146 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B002623 | CHEMBL1288608 | Small molecule | -- | 283.36 | C15H13N3OS | NEUTRAL | Details |
| B002624 | CHEMBL1288609 | Small molecule | -- | 240.31 | C15H16N2O | NEUTRAL | Details |
| B002625 | CHEMBL1288648 | Small molecule | -- | 270.33 | C16H18N2O2 | NEUTRAL | Details |
| B002626 | CHEMBL1288649 | Small molecule | -- | 272.32 | C16H17FN2O | NEUTRAL | Details |
| B002627 | CHEMBL1288650 | Small molecule | -- | 288.78 | C16H17ClN2O | NEUTRAL | Details |
| B002629 | CHEMBL1288702 | Small molecule | -- | 289.4 | C16H19NO2S | NEUTRAL | Details |
| B002658 | CHEMBL1289028 | Small molecule | -- | 347.83 | C16H14ClN3O2S | NEUTRAL | Details |
| B002659 | CHEMBL1289031 | Small molecule | -- | 436.58 | C21H32N4O4S | NEUTRAL | Details |
| B002662 | CHEMBL1289144 | Small molecule | -- | 343.41 | C17H17N3O3S | NEUTRAL | Details |
| B002663 | CHEMBL1289145 | Small molecule | -- | 362.25 | C15H12BrN3OS | NEUTRAL | Details |
| Article ID | PMID | Source | Title |
|---|