Therapeutic Target Details

Target ID: T43
Target Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Synonyms: Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1; TGF-β-activated kinase; TAK1
GENE: TAB1
Action: inhibitor
Class: Kinase
UniProtKB ID:Q15750
Entry Name: TAB1_HUMAN
Related Drugs: None
Mechanism: RNA-sequencing and multiomics analyses further indicated that the key mechanism linking the anti-NASH effects of breviscapine was inhibition of TGF-β-activated kinase 1 (TAK1) phosphorylation and the subsequent mitogen-activated protein kinase signaling cascade. Treatment with the TAK1 inhibitor 5Z-7-oxozeaenol abrogated breviscapine-mediated hepatoprotection under metabolic stress. Molecular docking illustrated that breviscapine directly bound to TAK1.
Reference (PMIDs): 34717002

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress

Candidate ID Source ID Source Type Compound Type Candidate Name Inclusion Criteria
R1092 DB06757 approved; nutraceutical small molecule Manganese Target associated Details

Compound ID Source ID Source Type Compound Name Molecular Weight Molecular Formula Molecular Species
B125762 CHEMBL3394102 Small molecule -- 438.48 C22H19FN4O3S ACID Details
B125763 CHEMBL3394105 Small molecule -- 480.57 C25H25FN4O3S ACID Details
B125764 CHEMBL3394108 Small molecule -- 482.54 C24H23FN4O4S ACID Details
B125765 CHEMBL3394112 Small molecule -- 558.63 C27H31FN4O6S ACID Details
B125766 CHEMBL3394118 Small molecule -- 613.5 C27H25FIN5OS NEUTRAL Details
B131862 CHEMBL3746293 Small molecule -- 529.6 C27H24FN7O2S NEUTRAL Details
B132740 CHEMBL388978 Small molecule STAUROSPORINE 466.54 C28H26N4O3 BASE Details
B132754 CHEMBL3891089 Small molecule -- 294.31 C16H14N4O2 NEUTRAL Details
B132814 CHEMBL3893882 Small molecule -- 273.34 C15H19N3O2 NEUTRAL Details
B132836 CHEMBL3894718 Small molecule -- 242.28 C13H14N4O NEUTRAL Details
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Article ID PMID Source Title