Therapeutic Target Details
| Target ID: | T44 |
| Target Name: | Amine oxidase, copper containing |
| Synonyms: | semicarbazide-sensitive amine oxidase (SSAO); vascular adhesion protein-1 (VAP-1); AOC3; Copper amine oxidase; HPAO; Membrane primary amine oxidase; Semicarbazide-sensitive amine oxidase; SSAO; VAP1; VAP-1; Vascular adhesion protein 1 |
| GENE: | AOC3 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | Q16853 |
| Entry Name: | AOC3_HUMAN |
| Related Drugs: | ECC0509 |
| Mechanism: | The elevations in hepatic VAP-1 expression reported in nonalcoholic steatohepatitis can contribute to steatosis, metabolic disturbance and inflammation. This suggests that targeting the semicarbazide sensitive amine oxidase capacity of VAP-1 may represent a useful adjunct to other therapeutic strategies in NAFLD. |
| Reference (PMIDs): | 33312420 |
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| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species |
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