Therapeutic Target Details
| Target ID: | T45 |
| Target Name: | Arachidonate 12-lipoxygenase |
| Synonyms: | 12LO; 12S-lipoxygenase; 12S-LOX; ALOX12; Arachidonate (12S)-lipoxygenase; Arachidonate (15S)-lipoxygenase; Linoleate (13S)-lipoxygenase; Lipoxin synthase 12-LO; LOG12; Platelet-type lipoxygenase 12; Polyunsaturated fatty acid lipoxygenase ALOX12 |
| GENE: | ALOX12 |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | P18054 |
| Entry Name: | LOX12_HUMAN |
| Related Drugs: | IMA-1 |
| Mechanism: | ALOX12 was shown to induce NASH by directly targeting acetyl-CoA carboxylase 1 (ACC1) via a lysosomal degradation mechanism. Overall, our findings reveal a key molecular driver of NASH pathogenesis and suggest that ALOX12-ACC1 interaction may be a therapeutic target in NASH. |
| Reference (PMIDs): | 34910546 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000008 | CHEMBL100473 | Small molecule | U-0126 | 380.5 | C18H16N6S2 | NEUTRAL | Details |
| B000059 | CHEMBL1018 | Small molecule | DIENESTROL | 266.34 | C18H18O2 | NEUTRAL | Details |
| B000238 | CHEMBL1076555 | Small molecule | -- | 302.79 | C15H11ClN2OS | NEUTRAL | Details |
| B000559 | CHEMBL1084441 | Small molecule | -- | 323.37 | C20H18FNO2 | NEUTRAL | Details |
| B000845 | CHEMBL1091556 | Small molecule | -- | 353.6 | C14H10BrClN2O2 | NEUTRAL | Details |
| B001109 | CHEMBL1129 | Small molecule | TRIFLURIDINE | 296.2 | C10H11F3N2O5 | NEUTRAL | Details |
| B001273 | CHEMBL116438 | Small molecule | CURCUMIN | 368.39 | C21H20O6 | NEUTRAL | Details |
| B001307 | CHEMBL116955 | Small molecule | CONGO RED | 652.71 | C32H24N6O6S2 | ACID | Details |
| B001416 | CHEMBL1172003 | Small molecule | -- | 494.66 | C28H34N2O4S | ACID | Details |
| B001512 | CHEMBL118 | Small molecule | CELECOXIB | 381.38 | C17H14F3N3O2S | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00982 | 34910548 | Sci Transl Med | A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. | Details |
| A00983 | 34910546 | Sci Transl Med | Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis. | Details |
| A07447 | 32492133 | J Biochem | Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice. | Details |
| A09225 | 31831037 | J Exp Clin Cancer Res | Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via ALOX12-12HETE-GPR31 signaling axis. | Details |
| A11529 | 30855277 | J Clin Invest | Resolving inflammation in nonalcoholic steatohepatitis. | Details |
| A11530 | 30855276 | J Clin Invest | A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. | Details |
| A15476 | 28886991 | J Diabetes Complications | Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase. | Details |
| A24975 | 22290395 | Hepatology | Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. | Details |
| A25653 | 21587068 | Curr Opin Clin Nutr Metab Care | The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease. | Details |
| A46117 | 20967760 | Hepatology | Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. | Details |
| A48625 | 32760397 | Front Immunol | Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis. | Details |