Therapeutic Target Details
| Target ID: | T46 |
| Target Name: | ATP-citrate synthase |
| Synonyms: | ACL; ACLY; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; Citrate cleavage enzyme |
| GENE: | ACLY |
| Action: | inhibitor |
| Class: | Transferase |
| UniProtKB ID: | P53396 |
| Entry Name: | ACLY_HUMAN |
| Related Drugs: | Bempedoic acid (ETC-1002) |
| Mechanism: | ATP citrate lyase (ACLY) is a cytoplasmic enzyme that responsible for the generation of acetyl coenzyme A (acetyl-CoA) in de novo lipogenesis and cholesterol synthesis. ACLY inhibitor, alleviates high-fat diet (HFD) induced NASH in male C57BL6/N mice, including decreased body weight gain, improved glycemic control, reduced hepatic TG and total cholesterol (TC), lowered mRNA expression of inflammatory and fibrotic genes (Ccl2, Timp1 and Col1a1), and improvement in NAS score.5 |
| Reference (PMIDs): | 34909677; 28153881 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B118007 | CHEMBL289277 | Small molecule | EMODIN | 270.24 | C15H10O5 | NEUTRAL | Details |
| B132111 | CHEMBL3771118 | Small molecule | -- | 283.28 | C13H17NO6 | ACID | Details |
| B134560 | CHEMBL399379 | Small molecule | -- | 424.31 | C19H15Cl2NO4S | ACID | Details |
| B136258 | CHEMBL4129274 | Small molecule | -- | 851.48 | C41H55ClN10O6S | NEUTRAL | Details |
| B136315 | CHEMBL414883 | Small molecule | RADICICOL | 364.78 | C18H17ClO6 | NEUTRAL | Details |
| B138263 | CHEMBL4444045 | -- | -- | 339.48 | C22H29NO2 | NEUTRAL | Details |
| B138321 | CHEMBL4446933 | -- | -- | 355.48 | C22H29NO3 | NEUTRAL | Details |
| B138445 | CHEMBL4452781 | -- | -- | 378.56 | C25H34N2O | NEUTRAL | Details |
| B138448 | CHEMBL4452883 | -- | -- | 378.56 | C25H34N2O | NEUTRAL | Details |
| B147499 | CHEMBL4065030 | Small molecule | -- | 363.37 | C17H14FNO5S | ACID | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00748 | 34981123 | Biosci Rep | Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture. | Details |
| A25056 | 33907358 | J Proteomics Bioinform | High Fat Diet-Induced Changes in Hepatic Protein Abundance in Mice. | Details |