Therapeutic Target Details
| Target ID: | T08 |
| Target Name: | Tumor necrosis factor |
| Synonyms: | Cachectin; TNF-a; TNF-alpha; TNFA; TNFSF2; Tumor necrosis factor ligand superfamily member 2; TNF |
| GENE: | TNF |
| Action: | inhibitor |
| Class: | Cytokine |
| UniProtKB ID: | P01375 |
| Entry Name: | TNFA_HUMAN |
| Related Drugs: | Pentoxifylline |
| Mechanism: | TIPE2 suppresses NAFLD advancement by blocking TAK1-JNK/p38 pathway and is a promising target molecule for NAFLD therapy. |
| Reference (PMIDs): | 33768585 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D137 | Fish oil | Biological drug | DB13961 | -- | -- | Under clinical trials | Details |
| D395 | Zinc | Chemical drug | DB01593 | PSPH; CCS; HDAC1 cofactor; HDAC4 cofactor; INS; UTRN; ASPA cofactor; TP73 cofactor; A2M; AGT; APOBR; APOE; APOL1; C3; C5; CFB; CFH; CFI; CLU; CP; CPN2; DSP; F12; F13B; FGA; GSN; HBB; HPR; JUP; SELENOP; TTR; VTN | -- | Under clinical trials | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0003 | DB00005 | approved; investigational | biotech | Etanercept | Therapeutic strategy associated | Details |
| R0017 | DB00051 | approved; experimental | biotech | Adalimumab | Therapeutic strategy associated | Details |
| R0020 | DB00065 | approved | biotech | Infliximab | Therapeutic strategy associated | Details |
| R0043 | DB00132 | approved; investigational; nutraceutical | small molecule | alpha-Linolenic acid | Therapeutic strategy associated | Details |
| R0054 | DB00154 | investigational; nutraceutical | small molecule | Dihomo-gamma-linolenic acid | Therapeutic strategy associated | Details |
| R0163 | DB00480 | approved | small molecule | Lenalidomide | Therapeutic strategy associated | Details |
| R0214 | DB00608 | approved; investigational; vet_approved | small molecule | Chloroquine | Target associated | Details |
| R0233 | DB00668 | approved; vet_approved | small molecule | Epinephrine | Target associated | Details |
| R0254 | DB00724 | approved; investigational | small molecule | Imiquimod | Therapeutic strategy associated | Details |
| R0305 | DB00843 | approved | small molecule | Donepezil | Therapeutic strategy associated | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000095 | CHEMBL103667 | Small molecule | DORAMAPIMOD | 527.67 | C31H37N5O3 | NEUTRAL | Details |
| B000118 | CHEMBL104584 | Small molecule | -- | 573.82 | C13H6Br4N2O4 | NEUTRAL | Details |
| B000135 | CHEMBL104991 | Small molecule | -- | 528.66 | C30H36N6O3 | NEUTRAL | Details |
| B000141 | CHEMBL105402 | Small molecule | -- | 351.3 | C18H13F4NO2 | NEUTRAL | Details |
| B000142 | CHEMBL105416 | Small molecule | -- | 323.24 | C16H9F4NO2 | NEUTRAL | Details |
| B000641 | CHEMBL108710 | Small molecule | -- | 435.43 | C21H25NO9 | NEUTRAL | Details |
| B000643 | CHEMBL1087180 | Small molecule | GANODERIC ACID B | 516.68 | C30H44O7 | ACID | Details |
| B000820 | CHEMBL109095 | Small molecule | TRICLOFENOL | 197.45 | C6H3Cl3O | NEUTRAL | Details |
| B000905 | CHEMBL109264 | Small molecule | -- | 444.49 | C26H24N2O5 | NEUTRAL | Details |
| B000938 | CHEMBL109316 | Small molecule | -- | 355.35 | C19H17NO6 | ACID | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00004 | 35258780 | Chin J Integr Med | Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease. | Details |
| A00203 | 35187967 | Exp Biol Med (Maywood) | Iron-accumulating splenocytes may exacerbate non-alcoholic steatohepatitis through the production of proinflammatory cytokines and reactive oxygen species. | Details |
| A00213 | 35182670 | J Ethnopharmacol | Gryllus bimaculatus De Geer hydrolysates alleviate lipid accumulation, inflammation, and endoplasmic reticulum stress in palmitic acid-treated human hepatoma G2 cells. | Details |
| A00251 | 35164657 | Bioengineered | Liraglutide inhibits receptor for advanced glycation end products (RAGE)/reduced form of nicotinamide-adenine dinucleotide phosphate (NAPDH) signaling to ameliorate non-alcoholic fatty liver disease (NAFLD) in vivo and vitro. | Details |
| A00342 | 35127372 | Acta Pharm Sin B | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. | Details |
| A00390 | 35104757 | Phytomedicine | Seed oil of Rosa roxburghii Tratt against non-alcoholic fatty liver disease in vivo and in vitro through PPARα/PGC-1α-mediated mitochondrial oxidative metabolism. | Details |
| A00430 | 35087037 | Cell Death Dis | Long-term oral administration of an HNF4α agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function. | Details |
| A00469 | 35069993 | World J Hepatol | Liver-side of inflammatory bowel diseases: Hepatobiliary and drug-induced disorders. | Details |
| A00490 | 35063810 | Nutrition | Satellite cell content and muscle regeneration in a mouse model of NAFLD. | Details |
| A00583 | 35040254 | Chem Biol Drug Des | SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice. | Details |
| A00658 | 35013040 | J Oleo Sci | Pink Lotus Essential Oil and Alleviates on Free Fatty Acid Induced Steatosis in HepG2 Cells via PI3K/Akt and NF-κB Pathways. | Details |
| A00666 | 35010924 | Nutrients | Lactoferrin Prevents Hepatic Injury and Fibrosis via the Inhibition of NF-κB Signaling in a Rat Non-Alcoholic Steatohepatitis Model. | Details |
| A00687 | 35003513 | Oxid Med Cell Longev | TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. | Details |
| A00775 | 34971904 | Biochem Biophys Res Commun | Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease. | Details |
| A00869 | 34944525 | Biomolecules | A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach. | Details |
| A00871 | 34944021 | Cells | IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. | Details |
| A00895 | 34938205 | Front Physiol | Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases. | Details |
| A00908 | 34933425 | Zhonghua Gan Zang Bing Za Zhi | [Intestinal flora polymorphisms with different lesional stages in an animal model of MAFLD]. | Details |
| A00946 | 34922604 | Trials | Omega-3 mechanism of action in inflammation and endoplasmic reticulum stress in mononuclear cells from overweight non-alcoholic fatty liver disease participants: study protocol for the "Brazilian Omega Study" (BROS)-a randomized controlled trial. | Details |
| A00950 | 34921696 | Biofactors | High-fat-induced nonalcoholic fatty liver potentiates vulnerability to and the severity of viral hepatitis in a C3H/HeN mouse model. | Details |