| Trial ID: | L0644 |
| Source ID: | IRCT201212052602N8
|
| Associated Drug: |
L-carnitine
|
| Title: |
Study of the Serum levels of miRNA-16, miRNA-21, miRNA-217 and effects of L-carnitine on their levels , TNF-a , TGF-?? cytokines, Malondialdehyde and CRP in Nonalcoholic Steatohepatitis (NASH) patients under weight loss regimen
|
| Acronym: |
--
|
| Status: |
Not Recruiting
|
| Study Results: |
No Results Available
|
| Results: |
--
|
| Conditions: |
Nonalcoholic steatohepatitis. <br>Nonalcoholic steatohepatitis( NASH);Nonalcoholic steatohepatitis( NASH)
|
| Interventions: |
Intervention 1: . Intervention group receives 2000 mg of L-carnitine as 2 vials,before the meals, for 12 weeks. Intervention 2: Control group receives 2000 mg of Placebo as 2 vials,before the meals, for 12 weeks.;Treatment - Drugs;Treatment - Drugs;. Inte
|
| Outcome Measures: |
TNF-a. Timepoint: At first of the study and 12th week. Method of measurement: labratory kit.;TGF-??. Timepoint: At first of the study and 12th week. Method of measurement: Sandwich Elisa.;Malondialdehide. Timepoint: At first of the study and 12th week. Method of measurement: Sandwich Elisa.;CRP. Timepoint: At first of the study and 12th week. Method of measurement: labratory kit.;MiRNA-16. Timepoint: At first of the study and 12th week. Method of measurement: RT-PCR.;MiRNA-21. Timepoint: At first of the study and 12th week. Method of measurement: RT-PCR.;MiRNA-217. Timepoint: At first of the study and 12th week. Method of measurement: RT-PCR.nan
|
| Sponsor/Collaborators: |
Vice Chancellor for Research of Tehran University of Medical Sciences
|
| Gender: |
All
|
| Age: |
18 years65 years
|
| Phases: |
Not applicable
|
| Enrollment: |
92
|
| Study Type: |
interventional
|
| Study Designs: |
Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment.
|
| Start Date: |
04/02/2013
|
| Completion Date: |
--
|
| Results First Posted: |
--
|
| Last Update Posted: |
22 February 2018
|
| Locations: |
Iran (Islamic Republic of)
|
| URL: |
http://en.irct.ir/trial/2379
|
